5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
CAS: 199596-24-2
Molecular Formula: C17H13ClN4
5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine - Names and Identifiers
5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine - Physico-chemical Properties
| Molecular Formula | C17H13ClN4 |
| Molar Mass | 308.76 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Boling Point | 472.9±55.0 °C(Predicted) |
| Solubility | DMSO: 10 mM |
| pKa | 11.00±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes . |
5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.239 ml | 16.194 ml | 32.388 ml |
| 5 mM | 0.648 ml | 3.239 ml | 6.478 ml |
| 10 mM | 0.324 ml | 1.619 ml | 3.239 ml |
| 5 mM | 0.065 ml | 0.324 ml | 0.648 ml |
Last Update：2024-01-02 23:10:35
5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine - Reference Information
| biological activity | Z-JIB-04 (NSC 693627, Ji B- 04 Z-isomer) is an isomer of Ji B- 04. Ji B- 04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 values of 230 nM, 340 nM, nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C and JMJD2D, respectively, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM. |
| Target | Value |
| JARID1A (Cell-free assay) | 230 nM |
| JMJD2D (Cell-free assay) | 290 nM |
| JMJD2E (Cell-free assay) | 340 nM |
| JMJD2B (Cell-free assay) | 435 nM |
| JMJD2A (Cell-free assay) | 445 nM |
Last Update：2024-04-09 20:49:11
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Product Name: (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE Visit Supplier Webpage Request for quotationCAS: 199596-24-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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