5-Chloro-2-ethoxyphenylboronic

5-Chloro-2-ethoxyphenylboronic - Names and Identifiers

Name	5-Chloro-2-ethoxyphenylboronic acid
Synonyms	C2196G1 542547_ALDRICH 5-Chloro-2-Ethoxyphenylboronic 5-Chloro-2-ethoxypheylboronic acid 5-CHLORO-2-ERHOXYPHENYLBORONIC ACID 2-Ethoxy-5-chlorophenylboronic acid 5-Chloro-2-ethoxyphenylboronic acid (5-Chloro-2-ethoxyphenyl)boronic acid B-(5-Chloro-2-ethoxyphenyl)boronicacid Boronic acid, (5-chloro-2-ethoxyphenyl)- (9CI) 5-Chloro-2-ethoxyphenylboronic acid(Contains varying amounts of anhydride)
CAS	352534-86-2
InChI	InChI=1/C8H10BClO3/c1-2-13-8-4-3-6(10)5-7(8)9(11)12/h3-5,11-12H,2H2,1H3

5-Chloro-2-ethoxyphenylboronic - Physico-chemical Properties

Molecular Formula	C8H10BClO3
Molar Mass	200.43
Density	1.27±0.1 g/cm3(Predicted)
Melting Point	120-124°C(lit.)
Boling Point	368.0±52.0 °C(Predicted)
Flash Point	176.4°C
Vapor Presure	4.58E-06mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
pKa	7.60±0.58(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.537

5-Chloro-2-ethoxyphenylboronic - Risk and Safety

Hazard Symbols	T+ - Very toxic
Risk Codes	R26 - Very Toxic by inhalation R34 - Causes burns R36 - Irritating to the eyes
Safety Description	S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany	3
Hazard Class	IRRITANT

5-Chloro-2-ethoxyphenylboronic - Introduction

Acid is an organic compound with the formula C8H10BClO3. The following is a description of some properties, uses, preparation and safety information about the compound:

Nature:
-Appearance: Colorless crystalline solid
-Melting point: about 89-92 degrees Celsius
-Soluble: Soluble in common organic solvents, such as ethanol and dimethylformamide

Use:
the acid is usually used as an intermediate in organic synthesis. Its main applications include the following:
-Ligand: It can be used as a ligand in metal-catalyzed reactions, such as copper-catalyzed C- C and C- O bond formation reactions.
-Substrate for cross-coupling reactions: It can undergo cross-coupling reactions with other compounds to form new compounds, which is beneficial to the expansion of organic synthesis.
-Drug synthesis: This compound is also used to synthesize active ingredients in drugs and pesticides.

Preparation Method:
The preparation method of calcium acid is relatively simple. A common method is to add 2-ethoxybenzene boric acid to ethanol and add cuprous chloride as a catalyst. Subsequently, copper chloride was added to the reaction as an oxidizing agent under heating. The reaction is typically carried out under an inert atmosphere such as nitrogen.

Safety Information:
The following safety measures should be observed when handling the calcium acid:
-Avoid contact with skin, eyes and respiratory tract. Appropriate protective gloves, safety glasses and masks should be worn.
-Work in a well-ventilated place during operation to prevent inhalation of harmful substances.
-If you come into contact with the compound, rinse immediately with plenty of water and seek medical assistance.
-During operation, pay attention to the source of fire, and properly store and dispose of the compound and its waste.

Last Update：2024-04-10 22:41:03