5-Chloro-alpha,alpha,alpha-trifluoro-2-picoline

5-Chloro-alpha,alpha,alpha-trifluoro-2-picoline - Names and Identifiers

Name	5-Chloro-2-(trifluoromethyl)pyridine
Synonyms	-Chloro-2-(trifluoroMethyl)pyridine 5-Chloro-2-(trifluoromethyl)pyridine 5-chloro-2-(trifluoromethyl) pyridine Pyridine, 5-chloro-2-(trifluoromethyl)- 5-Chloro-alpha,alpha,alpha-trifluoro-2-picoline
CAS	349-94-0

5-Chloro-alpha,alpha,alpha-trifluoro-2-picoline - Physico-chemical Properties

Molecular Formula	C6H3ClF3N
Molar Mass	181.54
Density	1.416±0.06 g/cm3(Predicted)
Melting Point	35-37°C
Boling Point	151-152 °C(Press: 744.6 Torr)
Flash Point	54℃
pKa	-1.73±0.22(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature

5-Chloro-alpha,alpha,alpha-trifluoro-2-picoline - Risk and Safety

Risk Codes	R11 - Highly Flammable R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	2926
WGK Germany	3
Hazard Class	IRRITANT, IRRITANT-H
Packing Group	Ⅲ

5-Chloro-alpha,alpha,alpha-trifluoro-2-picoline - Introduction

5-Chloro-2-(trifluoromethyl)pyridine is an organic compound with the formula C6H3ClF3N. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: colorless or yellowish liquid
-Melting point:-33 ℃
-Boiling point: 117-120 ℃
-Density: 1.46g/cm3
-Stability: relatively stable at room temperature, no flammability

Use:
- 5-Chloro-2-(trifluoromethyl)pyridine is an important organic synthesis intermediate, widely used in pharmaceutical and pesticide synthesis.
-It can be used as an intermediate in the manufacture of organic optoelectronic materials and coatings.

Preparation Method:
- 5-Chloro-2-(trifluoromethyl)pyridine has many preparation methods. The common method is to react benzyl magnesium iodide with trifluoroketone in the presence of pyridine. Specific reaction conditions can be adjusted according to specific laboratory conditions.

Safety Information:
- 5-Chloro-2-(trifluoromethyl)pyridine is generally safe under normal use, but the following precautions still need to be observed:
-Avoid contact with skin and eyes. If contact occurs, rinse immediately with plenty of water.
-Wear appropriate protective gloves, goggles and masks when in use.
-Use in a well-ventilated place, and keep away from fire and high temperature.
-Take care to avoid inhaling gas, mist or dust.
-Storage should be placed in a closed container, stored in a cool, dry place, away from oxidants and acids.

Last Update：2024-04-10 22:29:15