5-Chlorouridine
5-Chlorouridine
CAS: 2880-89-9
Molecular Formula: C9H11ClN2O6
5-Chlorouridine - Names and Identifiers
| Name | 5-Chlorouridine |
| Synonyms | 6-Cl-U NSC 146433 5-Chlorouridine 5-CHLOROURIDINE Uridine, 5-chloro- 5-Chloro-D-uridine 5-chloro-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione 5-chloro-1-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]pyrimidine-2,4-dione 5-CHLORO-1-[3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE 5-Chloro-1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| CAS | 2880-89-9 |
| EINECS | 1806241-263-5 |
| InChI | InChI=1/C9H11ClN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1 |
5-Chlorouridine - Physico-chemical Properties
| Molecular Formula | C9H11ClN2O6 |
| Molar Mass | 278.65 |
| Density | 1.80±0.1 g/cm3(Predicted) |
| Melting Point | 215-217°C |
| Solubility | DMSO (Slightly), Methanol, Water (Slightly, Sonicated) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 7.73±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.677 |
5-Chlorouridine - Introduction
5-Chlorouridine(5-Chlorouridine) is a nucleoside containing a chlorine atom with the chemical formula C9H11ClN2O6. It is a derivative of uracil (uridine), one of the common bases in RNA molecules.
The main properties of 5-Chlorouridine are as follows:
-Appearance: Colorless or white crystalline powder
-Solubility: Soluble in water and methanol
-Melting point: About 220-223 degrees Celsius
5-Chlorouridine has many applications in the field of medicine:
-Antiviral drugs: It can be used as an intermediate of antiviral drugs for the synthesis of anti-hepatitis B virus drugs.
-Anti-cancer research: Studies have shown that 5-Chlorouridine can improve the effectiveness of cancer treatment and has anti-cancer potential.
The main methods for preparing 5-Chlorouridine are as follows:
A common synthetic method is by the chlorination of uracil. The specific steps are as follows:
1. Uracil is dissolved in acidic medium, and chlorination reaction is carried out by adding chlorite (SOCl2).
2. The inorganic salts in the reaction mixture are removed by refrigerated centrifugation or filtration.
3. The obtained 5-chlorouracil can be purified by solvent volatilization or crystallization.
About safety information:
5-Chlorouridine has limited toxicity studies and therefore needs to be handled with caution. As a laboratory chemical reagent, it should be used and handled in accordance with safe practices. Direct contact with skin and eyes should be avoided, and inhalation or ingestion should be avoided. Personal protective equipment such as protective gloves, goggles and lab coats are recommended during use. If contact causes discomfort or maladjustment, seek medical attention immediately.
The main properties of 5-Chlorouridine are as follows:
-Appearance: Colorless or white crystalline powder
-Solubility: Soluble in water and methanol
-Melting point: About 220-223 degrees Celsius
5-Chlorouridine has many applications in the field of medicine:
-Antiviral drugs: It can be used as an intermediate of antiviral drugs for the synthesis of anti-hepatitis B virus drugs.
-Anti-cancer research: Studies have shown that 5-Chlorouridine can improve the effectiveness of cancer treatment and has anti-cancer potential.
The main methods for preparing 5-Chlorouridine are as follows:
A common synthetic method is by the chlorination of uracil. The specific steps are as follows:
1. Uracil is dissolved in acidic medium, and chlorination reaction is carried out by adding chlorite (SOCl2).
2. The inorganic salts in the reaction mixture are removed by refrigerated centrifugation or filtration.
3. The obtained 5-chlorouracil can be purified by solvent volatilization or crystallization.
About safety information:
5-Chlorouridine has limited toxicity studies and therefore needs to be handled with caution. As a laboratory chemical reagent, it should be used and handled in accordance with safe practices. Direct contact with skin and eyes should be avoided, and inhalation or ingestion should be avoided. Personal protective equipment such as protective gloves, goggles and lab coats are recommended during use. If contact causes discomfort or maladjustment, seek medical attention immediately.
Last Update：2024-04-09 20:49:11
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