5-FLUORO-2-METHOXYURACIL
5-Fluoro-2-methoxy-4(1H)pyrimidinone
CAS: 1480-96-2
Molecular Formula: C5H5FN2O2
5-FLUORO-2-METHOXYURACIL - Names and Identifiers
| Name | 5-Fluoro-2-methoxy-4(1H)pyrimidinone |
| Synonyms | 5-FLUORO-2-METHOXYURACIL 2-Methoxy-5-fluorouracil 2-O-METHYL-5-FLUOROURACIL 2-Methoxyl-5-fluorouracil 5-Fluoro-2-methoxy-pyrimidin-4-ol 5-Fluoro-2-methoxy-4(1H)pyrimidinone 5-Fluoro-2-methoxy-4(3H)-pyrimidinone 5-fluoro-2-methoxypyrimidin-4(3H)-one 4(1H)-Pyrimidinone, 5-fluoro-2-methoxy- (9CI) 2-METHOXY-5-FLUORO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE |
| CAS | 1480-96-2 |
| EINECS | 473-810-9 |
| InChI | InChI=1/C5H5FN2O2/c1-10-5-7-2-3(6)4(9)8-5/h2H,1H3,(H,7,8,9) |
| InChIKey | VMIFBCPINLZNNI-UHFFFAOYSA-N |
5-FLUORO-2-METHOXYURACIL - Physico-chemical Properties
| Molecular Formula | C5H5FN2O2 |
| Molar Mass | 144.1 |
| Density | 1.44±0.1 g/cm3(Predicted) |
| Melting Point | 204-208°C(lit.) |
| Boling Point | 225.1℃[at 101 325 Pa] |
| Water Solubility | 5.49g/L at 20℃ |
| Vapor Presure | 0.001Pa at 25℃ |
| pKa | 6.34±0.50(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.536 |
| MDL | MFCD04972330 |
5-FLUORO-2-METHOXYURACIL - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29335990 |
5-FLUORO-2-METHOXYURACIL - Reference Information
| LogP | -0.226 at 25℃ |
| Uses | 2-methoxy-5-fluorouracil is a uracil derivative, used as a pharmaceutical intermediate, used in pharmaceutical synthesis and experimental research. |
| Synthesis method | Acetamide and methyl chloroacetate are used as raw materials to prepare the key intermediate methyl fluoroacetate. The product is catalyzed by sodium methoxide and O-Methylisourea sulfate cyclize to obtain the target compound 2-methoxy-5-fluorouracil. The synthesis reaction formula is as follows: |
Last Update：2024-04-09 19:05:10
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