5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one
Prunetin
CAS: 552-59-0
Molecular Formula: C16H12O5
5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one - Names and Identifiers
5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one - Physico-chemical Properties
| Molecular Formula | C16H12O5 |
| Molar Mass | 284.26 |
| Density | 1.2160 (rough estimate) |
| Melting Point | 240-242°C |
| Boling Point | 346.76°C (rough estimate) |
| BRN | 292155 |
| pKa | 6.35±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.6200 (estimate) |
| Physical and Chemical Properties | Yellow powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., from Rosaceae plant flavor Li Prunus verecunda Koehne stem Li P.puddun bark Bignoniaceae plant wood butterfly Oroxylum indicum Vent. Glabra L., Glycyrrhiza glabra L.. |
| In vitro study | Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5 AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. |
5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | DJ3100050 |
| FLUKA BRAND F CODES | 10 |
5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one - Reference
| Reference Show more | 1. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 |
5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one - Reference Information
| Overview | elaeolin is an isoflavone substance of Prunus, which has anti-inflammatory and hypolipidemic effects, as well as phytoestrogen-like effects. There are few disclosures on the process of extraction of beta-luteum from plants, a multi-genus research-based process or a low-content extract. If Caragana Changdu as raw material, using 95% ethanol immersion extraction, the obtained extract by silica gel column repeated separation of 15 compounds, including the white pigment. In addition, red clover was extracted by reflux with 50% ethanol as raw material, the extract was concentrated and extracted with ethyl acetate, and then separated repeatedly by silica gel column and gel column to obtain 8 compounds including cherry yellow. A large amount of silica gel waste is generated in the production process of the existing preparation process of the product, and the operation is complicated and the reproducibility is poor. Therefore, it is necessary to provide a preparation of high purity of the pigment, and the pharmacological effects of the pigment can be better studied. |
| Use | Prunetin is widely found in Rose, Rose leaves, Sophora leaves and other plants, with anti-allergic, anti-inflammatory, anti-tumor and protection of cardiovascular and cerebrovascular and other biological activities. If research has developed a pharmaceutical composition containing trifoltin and/or beta-luteolin, through the action of selective estrogen receptor modulators widely distributed in the body, with the prevention and treatment of cardiovascular system and osteoporosis. It is also useful for the preparation of drugs for the treatment of cancer and drug lead compounds. The results showed that Ezrin had hypolipidemic effect. for content determination/identification/pharmacological experiments. |
| biological activity | Prunetin is an O-Methylated isoflavone with anti-inflammatory activity. Prunetin is a potent inhibitor of human aldehyde dehydrogenase. |
Last Update：2024-04-09 21:04:16
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Product Name: Prunetin Visit Supplier Webpage Request for quotationCAS: 552-59-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Prunetin Visit Supplier Webpage Request for quotationCAS: 552-59-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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