5-Hydroxy-6,7-dimethoxylflavone

Name	5-Hydroxy-6,7-dimethoxylflavone
Synonyms	5-Hydroxy-6,7-diMethoxyflavone 5-Hydroxy-6,7-dimethoxylflavone 5-Hydroxy-6,7-diMethoxylflavone Mosloflavone( 5-Hydroxy-6,7-dimethoxyflavone) 5-Hydroxy-6,7-diMethoxy-2-phenyl-4H-chroMen-4-one 5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-phenyl-
CAS	740-33-0

Molecular Formula	C17H14O5
Molar Mass	298.29
Density	1.321±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	163-164℃ (chloroform , acetone )
Boling Point	508.5±50.0 °C(Predicted)
Solubility	Almost insoluble (0.019g/L) (25°C)
Appearance	Yellow crystal
pKa	6.32±0.40(Predicted)
Storage Condition	2-8°C
MDL	MFCD00601540
Physical and Chemical Properties	Yellow crystal, soluble in methanol, ethanol, DMSO and other organic solvents, from Scutellaria baicalensis Georgi.
In vitro study	Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC 50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases.

Use	5-hydroxy-6, 7-dimethoxyflavone is a flavonoid, it can be used to prepare a pharmaceutical composition with synergistic effect against drug-resistant fungi, including azole antifungal drugs, A 2-substituted benzopyran-4-one compound or a pharmaceutically acceptable salt or hydrate thereof. for content determination/identification/pharmacological experiments, etc
biological activity	Mosloflavone a flavonoid isolated from Scutellaria baicalensis Georgi, has anti-ev71 activity. Mosloflavone inhibited VP2 Virus replication and protein expression and Virus VP2 capsid protein synthesis at the initial stage of Virus infection. Mosloflavone is a promising fungicide that inhibits the virulence of Pseudomonas aeruginosa and biofilm formation.
Target	IC50: EV71; bacterial

Last Update：2024-04-09 20:45:29