5-IODOTUBERICIDIN
5-Iodotubercidin
CAS: 24386-93-4
Molecular Formula: C11H13IN4O4
5-IODOTUBERICIDIN - Names and Identifiers
| Name | 5-Iodotubercidin |
| Synonyms | ITU IODOTUBERCIDIN 5-IODOTUBERCIDIN 5-Iodotubercidin 5-IODOTUBERICIDIN Iodotubercidin,Itu 7-IODO-7-DEAZAADENOSINE 4-Amino-5-iodo-7-(b-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 4-AMINO-5-IODO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE |
| CAS | 24386-93-4 |
| EINECS | 200-001-2 |
| InChIKey | WHSIXKUPQCKWBY-IOSLPCCCSA-N |
5-IODOTUBERICIDIN - Physico-chemical Properties
| Molecular Formula | C11H13IN4O4 |
| Molar Mass | 392.15 |
| Density | 2.49±0.1 g/cm3(Predicted) |
| Melting Point | 216-217°C dec. |
| Boling Point | 701.5±60.0 °C(Predicted) |
| Solubility | 0.1 M HCl: 0.7mg/mL |
| Appearance | solid |
| Color | tan |
| pKa | 12.33±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Store tightly sealed at 4°C; Light Sensitive |
| In vitro study | 5-Iodotubercidin(Itu) is a genotoxic drug that activates Atm-p53 pathways and has anti-tumor activity. Itu p53-dependently induced G2 phase arrest. At high concentrations, Itu may activate p53-dependent signaling pathways that may cooperate with p53 to kill cells, thereby inhibiting tumor growth. The incorporation of Itu metabolites into DNA will cause DNA breakage and cause DNA damage response. Itu may be a potential chemotherapy drug. |
| In vivo study | 5-Iodotubercidin is a potent inhibitor of adenosine kinase in rat brain. In mice, 5-iodotubercidin has the effects of lowering blood pressure, muscle relaxation, and lowering body temperature, and this effect can be inhibited by the adenosine receptor antagonist theophylline. Before the cerebral ischemic attack, 5-iodotubercidin at 1 mg/kg was not protective by intraperitoneal injection. |
5-IODOTUBERICIDIN - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29349990 |
5-IODOTUBERICIDIN - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.55 ml | 12.75 ml | 25.5 ml |
| 5 mM | 0.51 ml | 2.55 ml | 5.1 ml |
| 10 mM | 0.255 ml | 1.275 ml | 2.55 ml |
| 5 mM | 0.051 ml | 0.255 ml | 0.51 ml |
Last Update：2024-01-02 23:10:35
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