biological activity | BGC20-761 is a selective antagonist of 5-HT6 and dopamine receptors, the Ki values for D2 receptors are 20,69, and 140 nM, respectively. BGC20-761 can enhance long-term memory. BGC20-761 can be used for antipsychotic research. |
Animal Model:
| Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats |
Dosage:
| 2.5 mg/kg, 5 mg/kg and 10 mg/kg |
Administration:
| Administered (i.p.) immediately after the training session for the social recognition test |
Result:
| Administered alone did not show any difference in social recognition as compared to saline treated control animals.
However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition. |