5-Nitro-2-furfuraldehyde semicarbazone
Nitrofural
CAS: 59-87-0
Molecular Formula: C6H6N4O4
5-Nitro-2-furfuraldehyde semicarbazone - Names and Identifiers
| Name | Nitrofural |
| Synonyms | nfz furacin furacilin Nitrofural 2-nitrofuran Nitrofurazone 5-nitro-2-furaldehydsemicarbazone 5-Nitro-2-furaldehyde semicarbazole 2-Furaldehyde, 5-nitro-, semicarbazone 5-Nitro-2-furfuraldehyde semicarbazone 5-nitrofuran-2-carbaldehyde semicarbazone 5-nitro-2-furancarboxaldehydesemicarbazone 5-Nitro-2-furancarboxaldehyde semicarbazone 2-Furancarboxaldehyde, 5-nitro-, semicarbazone 2-[(5-nitro-2-furanyl)methylene]-hydrazinecarboxamid 2-[(5-nitro-2-furanyl)methylene]-hydrazinecarboxamide |
| CAS | 59-87-0 |
| EINECS | 200-443-1 |
| InChI | InChI=1/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+ |
| InChIKey | IAIWVQXQOWNYOU-FPYGCLRLSA-N |
5-Nitro-2-furfuraldehyde semicarbazone - Physico-chemical Properties
| Molecular Formula | C6H6N4O4 |
| Molar Mass | 198.14 |
| Density | 1.6031 (rough estimate) |
| Melting Point | 242-244 °C (lit.) |
| Boling Point | 335.43°C (rough estimate) |
| Flash Point | 2°C |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Solubility | Soluble in 4200 parts of water, 590 parts of ethanol, almost insoluble in ether and chloroform. |
| Appearance | Yellow crystalline powder |
| Color | Yellow to Dark Yellow |
| Merck | 14,6600 |
| BRN | 86403 |
| pKa | pKa 9.28± 0.03( EtOH,t =35±0.1,I=0.00) (Uncertain) |
| Storage Condition | 2-8°C |
| Sensitive | Light Sensitive |
| Refractive Index | 1.6500 (estimate) |
| MDL | MFCD00003225 |
| Physical and Chemical Properties | Melting point 236°C (dec.) water-soluble <0.1g/100 mL at 19°C |
| Use | Nitrofuran antibacterial drugs, mainly used for poultry, livestock and aquatic fish disease prevention, antibacterial |
5-Nitro-2-furfuraldehyde semicarbazone - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | LT7700000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29321900 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in rats (g/kg): 0.59 orally; 3.0 s.c. (Godwin) |
5-Nitro-2-furfuraldehyde semicarbazone - Upstream Downstream Industry
| Raw Materials | Acetic anhydride Urea hydrazine hydrate |
5-Nitro-2-furfuraldehyde semicarbazone - Reference
| Reference Show more | Liang Jinling, Tang Ke, Huang Yuxia et al. Molecular Simulation and validation of nitrofurazone Molecularly Imprinted Polymer [J]. Computer and applied chemistry 2018(5). |
5-Nitro-2-furfuraldehyde semicarbazone - Reference Information
| (IARC) carcinogen classification | 3 (Vol. 50) 1990 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| properties | nitrofurazone is a yellow crystalline powder, odorless, light in taste, but with a slightly bitter aftertaste, the color darkened under sunlight, melting and decomposition at 236-240 ℃. Slightly soluble in ethanol, very slightly soluble in water, almost insoluble in ether and chloroform. |
| pharmacological effects | furacilin can affect a variety of positive and negative bacteria, 1: 100000~1: 200000 solution has a bacteriostatic effect on most bacteria, and the bactericidal concentration is about twice as high as the inhibitory concentration. For some strains, however, they are not sensitive even at concentrations well above. For example, the efficacy against aerogenes, Proteus, Mycobacterium tuberculosis and diphtheria is poor, and the efficacy against Pseudomonas aeruginosa is even worse. |
| Application | nitrofurazone is a synthetic nitrofuran disinfectant for external use, it can interfere with the sugar metabolism process of bacteria and the function of oxidase system, so as to achieve the purpose of bacteriostasis or sterilization. The antibacterial spectrum of furacilin is wide, and it has a resistance to a variety of gram-positive and negative bacteria. It can inhibit general bacteria in vitro, and can kill bacteria when the concentration is high, the effect of external flushing or wet dressing on the treatment of body surface infection and skin disease is ideal, which has been vigorously promoted in clinical practice. |
| prohibited veterinary drugs | According to the 560th announcement of the Ministry of Agriculture, furacilin is a prohibited veterinary drug in China. As a synthetic antibacterial agent, it can be used for Disinfection preservation, but it is not easy to metabolize. The residues of furan metabolites in animal-derived foods can be passed to humans through the food chain. Long-term intake can cause various diseases, and have carcinogenic and teratogenic side effects on human body. It can inhibit the hematopoietic function of bone marrow, reduce the formation of liver protein and glycogen, and destroy the excretion function of Kidney. After long-term application, it can cause toxic liver dystrophy and blood coagulation time. |
| purpose | This product is nitrofuran antibacterial. Such drugs also include furazolidone, nitrofurantoin. Nitrofurazone oral toxicity, for surgical local or surface Disinfection. nitrofuran antibacterial drugs, mainly used for poultry, livestock and aquatic fish disease prevention, antibacterial |
| production method | 5-nitrofurfural is prepared from furfural by nitration, esterification and hydrolysis, after condensation with amino hydrochloride, furacilin was obtained. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50 590 mg/kg; Oral-mouse LD50: 249 mg/kg |
| flammability hazard characteristics | combustible, nitrogen oxide emission from fire scene |
| storage and transportation characteristics | The warehouse is low temperature, ventilated and dry, and stored separately from food raw materials |
| extinguishing agent | water, carbon dioxide, dry powder, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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Raw Materials for 5-Nitro-2-furfuraldehyde semicarbazone