5-Nitro-o-anisidine
2-Methoxy-5-nitroaniline
CAS: 99-59-2
Molecular Formula: C7H8N2O3
5-Nitro-o-anisidine - Names and Identifiers
5-Nitro-o-anisidine - Physico-chemical Properties
| Molecular Formula | C7H8N2O3 |
| Molar Mass | 168.15 |
| Density | 1.2068 |
| Melting Point | 117-119°C(lit.) |
| Boling Point | 337.07°C (rough estimate) |
| Flash Point | 119℃ |
| Water Solubility | Slightly soluble. |
| Solubility | 382mg/L in organic solvents at 20 ℃ |
| Vapor Presure | 0.04Pa |
| BRN | 879620 |
| pKa | 2.42±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Stability | Stable, but may be moisture sensitive. Incompatible with water, acids, strong oxidizing agents, acid chlorides, acid anhydrides, chloroformates, liquid anisidine. |
| Refractive Index | 1.6010 (estimate) |
| MDL | MFCD00007261 |
| Physical and Chemical Properties | Character orange-red needle-like crystals. melting point 118 ℃ soluble in acetone, methanol, ethanol, benzene, ethyl acetate, etc. Insoluble in petroleum ether. |
| Use | As dyes, pigments and intermediates in organic synthesis |
5-Nitro-o-anisidine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 2 |
| RTECS | BZ7175000 |
| TSCA | Yes |
| Hazard Note | Irritant |
5-Nitro-o-anisidine - Reference Information
| Color index | 37130 |
| LogP | 1.16 at 23℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 3 (Vol. 27, Sup 7) 1987 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | use as an intermediate in dyes, pigments, and organic synthesis use as a dye intermediate. as dyes, pigments and intermediates in organic synthesis |
| production method | is obtained by methoxylation and reduction of 2, 4-dinitrochlorobenzene. 1. Methoxylation molten 2, 4-dinitrochlorobenzene was added to the reaction pot followed by addition of methanol. After heating to about 40 °c, 30% sodium hydroxide solution was added quickly and then slowly in 4H, and the temperature was controlled at 58-60 °c. The end point of the reaction was that phenolphthalein test paper exhibited orange-red color to the liquid. 2, 4-dinitrophenyl methyl ether was obtained with a yield of 95%. 2. Reduction the methoxylated product was cooled to 30 °c and a 18% solution of sodium disulfide was added quickly and then slowly over a period of 4H. The reaction temperature was increased from 30 °c to 50 °c by degree. After the addition, the mixture was incubated at 50-55 ° C. For half an hour. After completion of the reaction, the reaction mixture was cooled to 20 ° C., press-filtered, washed and dried to obtain 2-methoxy-5-nitroaniline. The yield was 76%. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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