ChemBK
  • Home
  • Product Category

5-Pregnen-3beta-ol-20-one

Pregnenolone

CAS: 145-13-1

Molecular Formula: C21H32O2

  1. Home
  2. Product Category
  3. Chemical Reagents
  4. General analytical reagents
  5. 5-Pregnen-3beta-ol-20-one

5-Pregnen-3beta-ol-20-one - Names and Identifiers

Name Pregnenolone
Synonyms Pregnenolone
5-pregnenolone
DELTA5-PREGNENOLONE
5-pregnen-3B-ol-20-one
5-Pregnen-3beta-ol-20-one
3-hydroxypregn-5-en-20-one
3b-hydroxy-5-pregnen-20-one
DELTA5-PREGNEN-3B-OL-20-ONE
DELTA-5-PREGNENE-3B-OL-20-ONE
3beta-Hydroxy-5-pregnen-20-one
3BETA-HYDROXYPREGN-5-EN-20-ONE
DELTA5-PREGNEN-3BETA-OL-20-ONE
3BETA-HYDROXY-5-PREGNEN-20-ONE
3-beta-hydroxypregn-5-en-20-one
(3beta)-3-hydroxypregn-5-en-20-one
(3beta,9xi,14xi)-3-hydroxypregn-5-en-20-one
(3beta,8xi,9xi,14xi)-3-hydroxypregn-5-en-20-one
CAS 145-13-1
EINECS 205-647-4
InChI InChI=1/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18?,19?,20-,21+/m0/s1
InChIKey ORNBQBCIOKFOEO-QGVNFLHTSA-N

5-Pregnen-3beta-ol-20-one - Physico-chemical Properties

Molecular FormulaC21H32O2
Molar Mass316.48
Density1.0382 (rough estimate)
Melting Point188-190°C
Boling Point395.89°C (rough estimate)
Specific Rotation(α)28.5 º (c=1, EtOH)
Flash Point9℃
Water Solubility41mg/L(room temperature)
Solubility Soluble in chloroform. Insoluble in water.
Vapor Presure0-0Pa at 20-25℃
AppearanceWhite powder or crystal
ColorWhite to off-white
Merck7733
BRN2059026
pKa15.00±0.70(Predicted)
Storage ConditionRefrigerator
Refractive Index1.5344 (estimate)
MDLMFCD00003628
Physical and Chemical PropertiesMelting point 190-193°C
specific rotation 28.5 ° (c = 1, EtOH)
UseUsed as an intermediate for progesterone in medicine
In vitro studyPregnenolone dose-related induction of MAP2 induces the rate and extent of tubulin assembly, while progesterone, inactive by itself, counteracts the stimulatory effect of Pregnenolone. Pregnenolone induced an increase in microtubule assembly, resulting in a completely normal structure. Pregnenolone maintains microtubule abundance and promotes cell movement during the outsourcing process. In the mouse hippocampal cell line (HT-22), Pregnenolone caused a significant decrease in the localization of the GR nucleus. Pregnenolone has neuropathological neuroprotective effects against glutamate and beta amyloid.
In vivo studyIn intact male SCID mice and castrated animals, Pregnenolone maintained its in vivo proliferative activity and stimulated the growth of LNCaP tumor xenografts. Pregnenolone activates transcription via the LNCaP androgen receptor (AR), but not wild-type AR. In intact male SCID mice and castrated animals, Pregnenolone caused a significant decrease in astrocytes in the vicinity of the wound and caused a significant decrease in bromodeoxyuridine incorporation in rat active astrocytes. Pregnenolone leads to an increase in downstream neurosteroids such as allopregnanolone, which has a neuroprotective effect, increases neurogenesis, reduces apoptosis and inflammation, regulates the hypothalamic-pituitary-adrenal axis, and significantly increased the GABA(A) receptor response. Pregnenolone raises Pregnenolone sulfate, which is a neurosteroid that actively regulates NMDA receptors.

5-Pregnen-3beta-ol-20-one - Risk and Safety

Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
UN IDsUN 1648 3 / PGII
WGK Germany3
RTECSTU5560700
HS Code29372900
5-Pregnen-3beta-ol-20-one
Supplier List
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Pregnenolone Request for quotation
CAS: 145-13-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Pregnenolone Visit Supplier Webpage Request for quotation
CAS: 145-13-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Pregnenolone Request for quotation
CAS: 145-13-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Pregnenolone Request for quotation
CAS: 145-13-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Pregnenolone Visit Supplier Webpage Request for quotation
CAS: 145-13-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Pregnenolone Request for quotation
CAS: 145-13-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
View History
5-Pregnen-3beta-ol-20-one
  • Home
  • Product Category

© 2015, 2023 ChemBK.com All Rights Reserved | Build: 20230617001