ChemBK
  • Home
  • Product Category

5-Vinyl-2-THIOOXAZOLIDONE

Goitrine

CAS: 1072-93-1

Molecular Formula: C5H7NOS

  1. Home
  2. Product Category
  3. other
  4. other
  5. 5-Vinyl-2-THIOOXAZOLIDONE

5-Vinyl-2-THIOOXAZOLIDONE - Names and Identifiers

Name Goitrine
Synonyms GOITRINE
Goitrine
R-GOITRIN
R-Goitrin
Epigoitrin
BA-51-090278
5-VINYL-2-THIOOXAZOLIDONE
5-Vinyl-2-THIOOXAZOLIDONE
(-)5-VINYL-2-OXAZOLIDINETHIONE
(-)5-Vinyl-2-oxazolidinethione
(R)-5-Vinyl-2-oxazolidinethione
(5R)-5-Vinyloxazolidine-2-thione
(5R)-5β-Vinyloxazolidine-2-thione
5-ethenyl-1,3-oxazolidine-2-thione
(5R)-5-ethenyl-1,3-oxazolidine-2-thione
CAS 1072-93-1
EINECS 236-145-3
InChI InChI=1/C5H7NOS/c1-2-4-3-6-5(8)7-4/h2,4H,1,3H2,(H,6,8)

5-Vinyl-2-THIOOXAZOLIDONE - Physico-chemical Properties

Molecular FormulaC5H7NOS
Molar Mass129.18
Density1.170 (estimate)
Melting Point47.5°C
Boling Point150.6±43.0 °C(Predicted)
Specific Rotation(α)(c, 2.5 in CHCl3)+75.1
Flash Point44.9°C
Solubility DMSO (Slightly), Methanol (Slightly)
Vapor Presure3.81mmHg at 25°C
AppearanceWhite powder
ColorWhite to Off-White
pKa13.34±0.40(Predicted)
Storage ConditionAmber Vial, -20°C Freezer
Refractive Index1.5480 (estimate)
Physical and Chemical PropertiesRoot from Radix Isatidis (I. indigotica Fort.)

5-Vinyl-2-THIOOXAZOLIDONE - Risk and Safety

Safety Description24/25 - Avoid contact with skin and eyes.
HS Code29349990

5-Vinyl-2-THIOOXAZOLIDONE - Reference

Reference
Show more
1. Zou Jing, Chen Hui, Peng Yi, et al. Simultaneous Determination of 7 Components in Jiawei Ermiao Granules and Establishment of Fingerprint [J]. 2018 of Chinese Patent Medicine v.40(02):99-104.
2. Fu Yuxin, Chen Li, Wang Weijian, et al. Determination of Yichun in Compound Tu Achyranthes bidentata pharynx by HPLC [J]. Practical Drugs and Clinical 2015 18(010):1225-1227.
3. Wei Yajie, Zhang Zekun, Guan Yanling, et al. Study on HPLC Fingerprint and Multi-component Quantitative Analysis of Hugan Tablets [J]. Zhongnan Pharmacy, 2018, 016(001):31-34.
4. Liwei He, Fangtian Fan, Xianbang Hou, Hongyan Wu, Juan Wang, Huiqin Xu, Yun Sun, 4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell, International IMMUN
5. [IF = 3.943] Liwei He et al."4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell." int Immunopharmacol. 2017 Nov;52:245
6. [IF = 7.514] Ru Zhao et al."An efficient approach for simultaneously obtaining oil and epigoitrin from Orychophragmus violaceus seeds by microwave-mediated immiscible binary solvent extraction." Food Chem. 2022 Mar;372:131258

5-Vinyl-2-THIOOXAZOLIDONE - Reference Information

overview (R,S)-Gao yichun, medicine, this product is colorless needle crystal.
Isatis root is the dried root of Isatis indigotica Isatisindigotica Fort. It is one of the traditional antiviral Chinese medicines and has the effects of clearing away heat and detoxification, cooling blood and relieving pharynx. The 2010 edition of "Chinese Pharmacopoeia" used RP-HPLC to determine the content of R,S-Gouyichun in Radix Isatis to control its quality [2].
basic information plant source: isatis root

analysis method: HPLC-DAD or/and HPLC-ELSD
identification method: mass spectrometry (mass spectrometry), nuclear magnetic resonance (NMR)
R, S-Gao Yichun a high performance liquid chromatography method for the determination of R, S-Gao Yichun in isatis root granules, isatis root tea and compound isatis root granules has been established according to the current pharmacopoeia standards. the method is simple, stable, reliable and reproducible. The quality control method of Isatis root preparation is consistent with that of decoction pieces, which provides experimental data for improving the quality standard of Isatis root preparation and is of great significance to ensure its quality. In order to extract the target components in Radix Isatidis as complete as possible, five solvents, including water, methanol, 80% methanol, 50% methanol, 20% methanol and 0. 02% phosphoric acid water, were investigated respectively. The results showed that mg · g-1 was determined with water as the content of Table 2 R and S-Gouyichun. The solvent obtained from the sample solution has more extracted components, so pure water is selected as the extraction solvent. There is a big difference between R,S-Gao Yichun in commercially available isatis root preparations. The content of R,S-Gao Yichun in isatis root granules is 0. 010 6~0. 290 9 mg g- 1. In 3 batches of isatis root tea, only the products of Guangdong Heping Pharmaceutical Co., Ltd. contain R,S-Gao Yichun. In 8 batches of compound isatis root granules, only the products of Chongqing Heping Pharmaceutical Co., Ltd. and Chongqing Taiji Group's No.2 Chinese Medicine Factory contain R,S-Gao Yichun may be related to the raw materials and preparation process of isatis root decoction pieces selected by various manufacturers, so it is necessary to control the quality of isatis root preparation.
HPLC determination of content chromatographic conditions: Shiseido C18MG column (4. 6mm × 250mm,5 μm), mobile phase methanol-0.02% phosphoric acid solution (7: 93), chromatographic peak detection wavelength 190~400 nm; The detection wavelength is 245 nm, and the flow rate is 1. 0 m L min- 1, the column temperature is 30 ℃, and the injection volume is 10~20 μL. The number of theoretical boards shall not be less than 5,000 according to R,S-report and spring peak. See Figure 1. Fig. 1 reference substance and HPLCA. reference substance of the sample; B. isatis root granules; C. isatis root tea; D. compound isatis root granules

fig. 1 reference substance and HPLC
a. reference substance; B. isatis root granules; C. isatis root tea; D. compound isatis root granules; 1. R,S-Gao Yichun
the stability of (R,S) -gouyichun in colang jiedu ling granules taking (R,S) -gouyichun as the index, under the conditions of relative humidity 65% ± 5% at 25 ℃ 2 ℃, relative humidity 65% ± 5% at 30 ℃ 2 ℃ and relative humidity 75% ± 5% at 40 ℃ 2 ℃ respectively, after placing Ganmao Jiedu Ling Granules for 0, 1, 2, 3, 6, 9 and 12 months, (R,S) -Gao Yichun in Ganmao Jiedu Ling Granules was determined. Results (R,S) -Gao Yichun was basically stable under the 65% ± 5% conditions of 25 ℃ 2 ℃ relative humidity, and unstable under the conditions of 30 ℃ 2 ℃ relative humidity 65% ± 5% and 40 ℃ 2 ℃ relative humidity 75% ± 5%. Conclusion (R,S) -Gao Yichun in Ganmao Jiedu Ling Granules is unstable under the conditions of relative humidity 65% ± 5% at 30 ℃ 2 ℃ and relative humidity 75% ± 5% at 40 ℃ 2 ℃, and should not be used as the quality control index of Ganmao Jiedu Ling Granules.
References [1] Table to Yichun. Chengdu Purifa Technology Development Co., Ltd. [Citation Date 2017.08.29]
[2] Chinese Pharmacopoeia. One [S]. 2010:191.
[3] Shi Yanhong, Xie Zhiyong, Wu Yingchun, Li Yiming, Wang Rui, Wang Zhengtao. RP-HPLC Determination of R,S-Gao Yichun in Radix Isatidis Preparation [J/OL]. Chinese Journal of Experimental Formulas, 2011,17(08):128-130. (2011-03-03)
[4] Fang Yu, Zhang Yun, Li Qin. Stability Study of (R,S)-Gao Yichun in Ganmao Jiedu Ling Granules [J]. Chinese patent medicine, 2013,35(07):1484-1486.
use used for content determination/identification/pharmacological experiments, etc. Pharmacological effect: mainly used for anti-virus, cure cold.
Last Update：2024-04-09 19:05:09
5-Vinyl-2-THIOOXAZOLIDONE
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Goitrine Visit Supplier Webpage Request for quotation
CAS: 1072-93-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Goitrine Request for quotation
CAS: 1072-93-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Epigoitrin Visit Supplier Webpage Request for quotation
CAS: 1072-93-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Goitrine Visit Supplier Webpage Request for quotation
CAS: 1072-93-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Goitrine Request for quotation
CAS: 1072-93-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Epigoitrin Visit Supplier Webpage Request for quotation
CAS: 1072-93-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
5-Vinyl-2-THIOOXAZOLIDONE
sauredesphytins
110032-20-7
  • Home
  • Product Category

© 2015, 2023 ChemBK.com All Rights Reserved | Build: 20230617001