5-chloro-1H-indole-3-carbonitrile
5-CHLORO-3-CYANOINDOLE
CAS: 194490-14-7
Molecular Formula: C9H5ClN2
5-chloro-1H-indole-3-carbonitrile - Names and Identifiers
| Name | 5-CHLORO-3-CYANOINDOLE |
| Synonyms | 5-CHLORO-3-CYANOINDOLE 5-chloro-1H-indole-3-carbonitrile 5-chloro -1H-indole-3-carbonitrile 1H-INDOLE-3-CARBONITRILE, 5-CHLORO- 5-CHLORO-1H-INDOLE-3-CARBONITRILE5-CHLORO-3-CYANOINDOLE |
| CAS | 194490-14-7 |
| InChI | InChI=1/C9H5ClN2/c10-7-1-2-9-8(3-7)6(4-11)5-12-9/h1-3,5,12H |
5-chloro-1H-indole-3-carbonitrile - Physico-chemical Properties
| Molecular Formula | C9H5ClN2 |
| Molar Mass | 176.6 |
| Density | 1.41 |
| Melting Point | 198-199 °C |
| Boling Point | 383.8±22.0 °C(Predicted) |
| Flash Point | 185.9°C |
| Vapor Presure | 4.28E-06mmHg at 25°C |
| pKa | 13.69±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.686 |
5-chloro-1H-indole-3-carbonitrile - Introduction
5-choro-3-cyanoindole is an organic compound with the chemical formula C11H5ClN2. The following is a description of its nature, use, preparation and safety information:
1. Nature:
-Appearance: 5-CHLORO-3-CYANOINDOLE is a yellow to yellow-green crystalline powder.
-Solubility: Soluble in organic solvents such as alcohol, ether and benzene, slightly soluble in water.
-Melting point: about 165-170 ° C.
-Stability: relatively stable at room temperature.
2. Use:
5-choro-3-cyanoindole is an important organic synthesis intermediate, which has a wide range of applications in the field of medicine and pesticide. It can be used as a starting material for conversion into other indole derivatives, including for the synthesis of anticancer drugs, antiviral drugs, and antibacterial agents, among others. In addition, it can also be used in the synthesis of dyes, photosensitizers and coatings.
3. Preparation method:
There are many preparation methods for 5-choro-3-cyanoindole, and common methods include the following:
-React indole with chlorine and cyanide: React indole with chlorine and cyanide to generate 5-CHLORO-3-CYANOINDOLE.
-reduction after indole nitration reaction: first, indole is nitrated to obtain nitroindole compound, and then reduction reaction is carried out to generate 5-CHLORO-3-CYANOINDOLE.
4. Safety Information:
- 5-CHLORO-3-CYANOINDOLE should be kept away from heat, fire and oxidant. In the storage and handling should comply with the appropriate safety procedures and precautions.
-Personal protective equipment such as glasses, face shield and gloves should be worn during operation.
-If the skin or eyes are touched, rinse immediately with plenty of water and seek medical attention.
-Keep it out of reach of children and avoid ingestion and inhalation.
1. Nature:
-Appearance: 5-CHLORO-3-CYANOINDOLE is a yellow to yellow-green crystalline powder.
-Solubility: Soluble in organic solvents such as alcohol, ether and benzene, slightly soluble in water.
-Melting point: about 165-170 ° C.
-Stability: relatively stable at room temperature.
2. Use:
5-choro-3-cyanoindole is an important organic synthesis intermediate, which has a wide range of applications in the field of medicine and pesticide. It can be used as a starting material for conversion into other indole derivatives, including for the synthesis of anticancer drugs, antiviral drugs, and antibacterial agents, among others. In addition, it can also be used in the synthesis of dyes, photosensitizers and coatings.
3. Preparation method:
There are many preparation methods for 5-choro-3-cyanoindole, and common methods include the following:
-React indole with chlorine and cyanide: React indole with chlorine and cyanide to generate 5-CHLORO-3-CYANOINDOLE.
-reduction after indole nitration reaction: first, indole is nitrated to obtain nitroindole compound, and then reduction reaction is carried out to generate 5-CHLORO-3-CYANOINDOLE.
4. Safety Information:
- 5-CHLORO-3-CYANOINDOLE should be kept away from heat, fire and oxidant. In the storage and handling should comply with the appropriate safety procedures and precautions.
-Personal protective equipment such as glasses, face shield and gloves should be worn during operation.
-If the skin or eyes are touched, rinse immediately with plenty of water and seek medical attention.
-Keep it out of reach of children and avoid ingestion and inhalation.
Last Update：2024-04-09 20:52:54
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Product Name: 5-CHLORO-3-CYANOINDOLE Visit Supplier Webpage Request for quotation
CAS: 194490-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 194490-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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