5-chloro-2,1,3-benzothiadiazol-4-amine - Names and Identifiers
Name | 4-Amino-5-chloro-2,1,3-benzothiadiazole
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Synonyms | TIZANIDINE EP IMPURITY E Tizanidin Related Compound A 5-chloro-2,1,3-benzothiadiazol-4-amine 4-AMINO-5-CHLORO-2,1,3-BENZOTHIODIAZOLE 5-Chloro-4-Amino-1,2,3-Benzothiadiazole 5-chloro-4-amino-2,1,3-benzothiadiazole 4-AMINO-5-CHLORO-1,2,3-BENZOTHIADIAZOLE 4-Amino-5-chloro-2,1,3-benzothiadiazole 5-Chloro-2,1,3-benzothiadiazol-4-ylamine (115398-34-0) 4-amino-5-chloro-2,1,3-benzothiadiazole
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CAS | 30536-19-7
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EINECS | 1308068-626-2 |
InChI | InChI=1/C6H4ClN3S/c7-3-1-2-4-6(5(3)8)10-11-9-4/h1-2H,8H2 |
5-chloro-2,1,3-benzothiadiazol-4-amine - Physico-chemical Properties
Molecular Formula | C6H4ClN3S
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Molar Mass | 185.63 |
Density | 1.632±0.06 g/cm3(Predicted) |
Melting Point | 89 °C |
Boling Point | 316.4±22.0 °C(Predicted) |
Flash Point | 145.1°C |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 0.000412mmHg at 25°C |
Appearance | neat |
Color | Brown |
pKa | -0.16±0.48(Predicted) |
Storage Condition | -20°C Freezer |
Refractive Index | 1.781 |
MDL | MFCD00465908 |
5-chloro-2,1,3-benzothiadiazol-4-amine - Risk and Safety
5-chloro-2,1,3-benzothiadiazol-4-amine - Introduction
Nature:
-Appearance: 4-Amino-5-chloro-2,1,3-benzothiadiazole is a white or pale yellow crystalline powder.
-Solubility: It is almost insoluble in water, but soluble in organic solvents such as chloroform and alcohol.
-Stability: 4-Amino-5-chloro-2,1,3-benzothiadiazole is a stable compound, it will not easily decompose at room temperature.
Use:
- 4-Amino-5-chloro-2,1,3-benzothiadiazole is commonly used in the preparation of dyes and pigments, especially as a component of blue and green dyes.
-It is also used as an intermediate in organic synthesis for the synthesis of other compounds.
Method:
- 4-Amino-5-chloro-2,1,3-benzothiadiazole can be obtained by reacting benzothiadiazole with nitrosomethane. Specific steps include:
1. Benzothiadiazole is dissolved in alcohol solvent.
2. Slowly add nitrosomethane at low temperature.
3. After the reaction, 4-Amino-5-chloro-2,1,3-benzothiadiazole was precipitated.
4. Further purification can be carried out by methods such as crystallization or column chromatography.
Safety Information:
- 4-Amino-5-chloro-2,1,3-benzothiadiazole has no obvious harm to human body and environment under normal circumstances.
-When using or handling, follow appropriate laboratory safety practices, including wearing protective gloves, glasses, and laboratory coats.
-When in contact with skin or eyes, rinse immediately with plenty of water. Seek professional medical help if necessary.
-When using or storing, avoid contact with strong oxidants and combustibles to prevent danger.
Last Update:2024-04-09 15:17:56