5-chloro-6-fluoropyridin-3-ol

5-chloro-6-fluoropyridin-3-ol - Names and Identifiers

Name	5-chloro-6-fluoropyridin-3-ol
Synonyms	5-CHLORO-6-FLUORO-3-PYRIDINOL 5-chloro-6-fluoropyridin-3-ol 6-chloro-5-fluoro-3-pyridinol 3-pyridinol, 5-chloro-6-fluoro- 3-Pyridinol, 5-chloro-6-fluoro- 3-Pyridinol,5-chloro-6-fluoro-(9CI) 3-CHLORO-2-FLUORO-5-HYDROXYPYRIDINE 2-FLUORO-3-CHLORO-5-HYDROXYPYRIDINE
CAS	209328-72-3
InChI	InChI=1/C5H3ClFNO/c6-4-1-3(9)2-8-5(4)7/h1-2,9H

5-chloro-6-fluoropyridin-3-ol - Physico-chemical Properties

Molecular Formula	C5H3ClFNO
Molar Mass	147.53
Density	1.517
Boling Point	354.4±37.0 °C(Predicted)
Flash Point	168.1°C
Vapor Presure	1.65E-05mmHg at 25°C
Appearance	Solid
pKa	8.25±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.552

5-chloro-6-fluoropyridin-3-ol - Introduction

Is an organic compound with the chemical formula C5H3ClFNO, which is a white crystalline solid. The following is a detailed description of the properties, uses, methods of manufacture and safety information:

Nature:
-Appearance: White crystalline solid.
-Solubility: It is not easily soluble with water, but can be dissolved in organic solvents, such as ethanol and methyl ether.
-Melting point: Its melting point is about 74-80°C.
-Chemical properties: It is a compound containing hydroxyl, chlorine and fluorine atoms, and has certain chemical reactivity.

Use:
-Pharmaceutical field: As a drug intermediate, it can be used to synthesize a variety of drugs, such as antibiotics and antiviral drugs.
-Pesticide field: It can also be used as a raw material for pesticides to prevent and control plant diseases and insect pests.

Method:
There are various preparation methods, the following is a common preparation method:
First, 2-amino-5-hydroxypyridine is reacted with trifluoroacetic acid to produce 2-trifluoroacetyl-5-hydroxypyridine. Then 2-trifluoroacetyl -5-hydroxyl pyridine and chlorinated carbonyl reaction, you can get.

Safety Information:
-should be away from fire and high temperature, avoid contact with strong oxidants.
-Wear appropriate protective equipment, such as chemical protective gloves and masks, to ensure that the operation is carried out in a well-ventilated place.
-In case of accidental ingestion or inhalation, seek medical advice immediately and show this safety data sheet.
-During storage, store it in a dry, cool, well-ventilated place away from direct sunlight.

Last Update：2024-04-09 21:01:54