5-chloro-6-hydroxypyridazin-4(1H)-one

5-chloro-6-hydroxypyridazin-4(1H)-one - Names and Identifiers

Name	5-Chloro-6-hydroxy-1H-pyridazin-4-one
Synonyms	4-Chloro-5-hydroxypyridazin-3(2H)-one 4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE 5-chloro-6-hydroxypyridazin-4(1H)-one 5-Chloro-6-hydroxy-1H-pyridazin-4-one 5-chloro-4-hydroxy-1H-pyridazin-6-one 3(2H)-Pyridazinone, 4-chloro-5-hydroxy-
CAS	64178-58-1
InChI	InChI=1/C4H3ClN2O2/c5-3-2(8)1-6-7-4(3)9/h1H,(H2,7,8,9)

5-chloro-6-hydroxypyridazin-4(1H)-one - Physico-chemical Properties

Molecular Formula	C4H3ClN2O2
Molar Mass	146.53
Density	1.79±0.1 g/cm3(Predicted)
Melting Point	270-273 °C(Solv: N,N-dimethylformamide (68-12-2))
Boling Point	213.3°C at 760 mmHg
Flash Point	82.8°C
Vapor Presure	0.0367mmHg at 25°C
pKa	4.50±1.00(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.681

5-chloro-6-hydroxypyridazin-4(1H)-one - Reference Information

Use

4-chloro-5-hydroxy 3(2H)-pyridazine is an organic intermediate.

preparation

Wagner et al. reported that it can be prepared from 4, 5-dichloropyridazin-3 (2H).-The ketone was prepared as a starting material. 4, 5-dichloropyridazin-3 (2H)-One (2G, 12mmol) was refluxed in 20ml 8N KOH for 6 hours. After acidification with HCl, the reaction mixture was concentrated in vacuo and extracted with ethyl acetate to give 4-chloro-5-hydroxy3 (2H)-pyridazine. Yield 0.69g,54%. m.p.267-272°C(from DMF),Lit.270-273°C.IR:2300-3340re, B, 1650M, 1595s,1555shcm-1. 1h-nmr (DMSO-d6):δ = 7.7(s,HatC-6),12.9(s, B, NH).C4H3C1N2O2(146.5);calcd.C32.78,H2.06,N19.12; Foundation c32.75, H2.17, n19.06.

Last Update：2024-04-09 15:16:40