5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt
Amobarbital Sodium
CAS: 64-43-7
Molecular Formula: C11H19N2NaO3
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Names and Identifiers
| Name | Amobarbital Sodium |
| Synonyms | Amytal Sodium Amobarbital Sodium Amylobarbital Sodium amylobarbitone sodium amobarbital sodium drug standard 5-ethyl-5-isopentyl-barbituricacisodiumsalt 5-ethyl-5-isopentylbarbituricacidsodiumsalt 5-ethyl-5-isopentyl-barbituricacisodiumderiv. 5-ethyl-5-(3-methylbutyl)barbituricacidsodiumderivative 5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt |
| CAS | 64-43-7 |
| EINECS | 200-584-9 |
| InChI | InChI=1/C11H18N2O3.Na/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1 |
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Physico-chemical Properties
| Molecular Formula | C11H19N2NaO3 |
| Molar Mass | 250.27 |
| Flash Point | 11 °C |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Sodium amobarbital is a white granule or powder. Odorless, bitter, hygroscopic. Amobarbital sodium is very soluble in water, soluble in alcohol, almost insoluble in ether and chloroform, aqueous solution was alkaline reaction. |
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CQ5250000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orl-rat: 275 mg/kg JPETAB 68,22,40 |
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Standard
Authoritative Data Verified Data
This product is 5-ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5h)-pyrimidinetrione monosodium salt. Calculated as dry product, containing no less than 98.5% of C11H17N2Na03.
Last Update：2024-01-02 23:10:35
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Trait
Authoritative Data Verified Data
- This product is a white particle or powder; Odorless; Has hygroscopicity; Aqueous alkaline reaction.
- This product is very soluble in water, soluble in ethanol, almost insoluble in chloroform or ether.
Last Update：2022-01-01 11:54:32
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Differential diagnosis
Authoritative Data Verified Data
- take about 0.5g of this product, Add 10ml of water to dissolve, add 0.5ml of hydrochloric acid to precipitate white precipitate of amobarbital, filter, wash the precipitate with water, dry at 105°C, according to the law (General Principles 0612 first method), the melting point is 155~158.5.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 164).
- This product shows the identification reaction of malonylurea (General rule 0301).
- take about lg of this product, after ignition, identify the reaction of sodium salt (General rule 0301).
Last Update：2022-01-01 11:54:33
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Exam
Authoritative Data Verified Data
alkalinity
take L. 0g of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 9.5~11.0.
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing about 1 mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the test of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane as filler; 3.0±0.1 mol /L potassium dihydrogen phosphate solution (adjusted to pH with phosphoric acid)-acetonitrile (65:35) it is a mobile phase, and the detection wavelength is 220mn; The number of theoretical plates is not less than 2500 according to the calculation of the peak of amobarbital, and the resolution of the peak of amobarbital and the adjacent impurity peaks should meet the requirements. 5ul of the control solution and 5ul of the test solution were injected into the liquid chromatograph respectively, and the chromatogram was recorded to 5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
loss on drying
take this product, dry to constant weight at 130°C, weight loss shall not exceed 4.0% (General rule 0831).
Heavy metals
take this product l. Add 43ml of water to dissolve, slowly add 3ml of dilute hydrochloric acid, shake and filter with strong shaking, take 23ml of continued filtrate, and add 2ml of acetate buffer (pH 3.5), inspection according to law (General Principles 0821, Law 1), containing heavy metals shall not exceed 20 parts per million.
bacterial endotoxin
take this product, check according to law (General rule 1143), each 1 mg of amobarbital sodium containing endotoxin amount should be less than 0.40EU. (For injection)
sterile
take this product, add 0.1% sterile peptone aqueous solution to make a solution containing 50mg per lml, and use membrane filtration method to treat, the amount of washing liquid is not less than 300ml, after washing in several times, inspection in accordance with the law (General rule 1101), should comply with the provisions. (For aseptic dispensing)
Last Update：2022-01-01 11:54:33
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, according to the method of amobarbital determination. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 24.83mg of C11H17N2Na03.
Last Update：2022-01-01 11:54:34
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Category
Authoritative Data Verified Data
anticonvulsants.
Last Update：2022-01-01 11:54:34
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Storage
Authoritative Data Verified Data
under shading, sealed and preserved.
Last Update：2022-01-01 11:54:34
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt - Amobarbital sodium for injection
Authoritative Data Verified Data
This product is a sterile powder of sodium amobarbital. The content of sodium amobarbital (C11H17N2Na03) shall be between 93.0% and 107.0% of the label weight, calculated as the average loading.
trait
This product is white granules or powder.
identification
This product was taken and the same results were shown according to the tests of (1), (3) and (4) under the item of sodium amobarbital.
examination
- alkalinity: take 0.50g of this product, Add 10ml of water to dissolve, and check according to law (General rule 0631). The pH value should be 9.5~11.0.
- Related substances take this product, add mobile phase to dissolve and dilute to prepare a solution containing about 1 mg of sodium amobarbital per 1 ml as a test solution; Take 1 ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. Determination of related substances according to the method of sodium amobarbital. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
- weight loss on drying this product shall be dried at 130°C to constant weight, and the weight loss shall not exceed 5.0% (General rule 0831).
- bacterial endotoxin this product, according to the law to check (General 1143), each 1 mg of amobarbital sodium containing endotoxin should be less than 0.40EU.
- sterile take this product, add 0.1% sterile peptone aqueous solution to make a solution containing 50mg of sodium amobarbital per 1 ml, and use membrane filtration method to treat it. The amount of flushing solution should not be less than 300ml, inspection in accordance with the law (General rule 1101), should comply with the provisions.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take the content of about 0.2g, precision weighing, according to the method under the item of amobarbital, per 1 ml of silver nitrate titration solution (0.1 mol/L) equivalent to 24.83mg of C11H17N2Na03. The content of C11H17N2Na03 in the test product is calculated according to the dried product, and then calculated according to the average loading.
category
with sodium amobarbital.
specification
(1)0.lg (2)0.25g
storage
light shielding, closed storage.
Last Update：2022-01-01 11:54:35
