5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione
5-Fluorouridine
CAS: 316-46-1;77180-80-4
Molecular Formula: C9H11FN2O6
5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione - Names and Identifiers
| Name | 5-Fluorouridine |
| Synonyms | FURD 5-fur FLUOROURIDINE 5-fluoro-uridin 5-Fluorouridine Uridine, 5-fluoro- 5-Fluorouracil-1beta-D-ribofuranoside 5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione 1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-fluoropyrimidine-2,4-dione 1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1 |
| CAS | 316-46-1 77180-80-4 |
| EINECS | 206-260-3 |
| InChI | InChI=1/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m0/s1 |
5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione - Physico-chemical Properties
| Molecular Formula | C9H11FN2O6 |
| Molar Mass | 262.19 |
| Density | 1.4200 (estimate) |
| Melting Point | 182-184°C |
| Specific Rotation(α) | 17 º (c=2, water 25 ºC) |
| Water Solubility | soluble |
| Solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming) |
| Appearance | Powder |
| Color | White |
| BRN | 33662 |
| pKa | 7.63±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months. |
| Refractive Index | 18 ° (C=1, H2O) |
| MDL | MFCD00036832 |
| Use | Intermediates, genetic engineering and biochemical reagents for the production of antitumor drugs DFUR and FUDR |
5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione - Risk and Safety
| Risk Codes | R40 - Limited evidence of a carcinogenic effect R68 - Possible risk of irreversible effects R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | YU8050000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29349990 |
| Hazard Note | Harmful |
5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione - Reference
| Reference Show more | 1. Dai Chun-guang, Lin Teng, Lu Chuan-hua, etc. Preparation, in vitro evaluation and in vivo pharmacokinetics of Zein adhesion controlled release tablets [J]. Progress in pharmacy, 2011, 35(004):174-177. |
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