5-formyltetrahydrofolate

Name	5-formyltetrahydrofolic acid
Synonyms	leucoverin Folinic Acid 5-formyltetrahydrofolate N5-formyl-tetrahydrofolate 5-formyltetrahydrofolic acid 5-formyl-5,6,7,8-tetrahydrofolate N5-formyl-5,6,7,8-tetrahydrofolate 5-formyl-5,6,7,8-tetrahydropteroyl-l-glutamicacid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid 2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
CAS	58-05-9
EINECS	200-361-6
InChI	InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1

Molecular Formula	C20H23N7O7
Molar Mass	473.44
Density	1.4485 (rough estimate)
Melting Point	245°C (rough estimate)
Boling Point	573.92°C (rough estimate)
Specific Rotation(α)	D20 +14.26° (c = 3.42 as anhydr Ca salt)
Water Solubility	>1350g/L(25 ºC)
pKa	3.1, 4.8, 10.4(at 25℃)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.6800 (estimate)
In vitro study	MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .

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5-formyltetrahydrofolate

5-formyltetrahydrofolate Request for Quotation