Name | 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile |
Synonyms | 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile |
CAS | 951753-87-0 |
Molecular Formula | C8H2F3N3S |
Molar Mass | 229.18 |
Boling Point | 367.7±42.0 °C |
Storage Condition | 2-8℃ |
Nature:
The compound is a colorless crystalline solid that is stable at ambient temperature. It has a strong odor and is insoluble in water, but soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane.
Use:
5-isothiocyanato-3-(trifluoromethyl)picolinonitrile are commonly used in amination reactions and electrophilic substitution reactions in organic synthesis. It can be used as a chemical reagent for the synthesis of other organic compounds, such as pharmaceuticals, pesticides and so on.
Preparation Method:
The preparation of 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile can be completed by reacting 3-(trifluoromethyl) pyridin -2-amine with isothiocyanate in dimethyl sulfoxide.
Safety Information:
When using 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile, care should be taken to avoid direct contact with the skin and inhalation of its dust. It may have irritating and corrosive effects on the eyes, skin and respiratory system. Appropriate protective equipment should be worn to ensure operation in a well-ventilated area, and attention should be paid to reasonable protective measures.