5-methylpyrimidin-2(1H)-one

5-methylpyrimidin-2(1H)-one - Names and Identifiers

Name	5-methylpyrimidin-2(1H)-one
Synonyms	5-Methyl-2-Pyrimidone 5-methyl-2-pyrimidinone 2-pyrimidinol, 5-methyl- 5-methylpyrimidin-2(1H)-one 5-Methylpyrimidin-2(1H)-one 5-Methyl-2(1H)-pyrimidinone 2-Hydroxy-5-methylpyrimidine 2(1H)-pyrimidinone, 5-methyl- 2(1H)-Pyrimidinone, 5-methyl- 5-Methylpyrimidin-2-ol hydrochloride 2(1H)-Pyrimidinone, 5-methyl- (7CI,9CI)
CAS	41398-85-0
InChI	InChI=1/C5H6N2O/c1-4-2-6-5(8)7-3-4/h2-3H,1H3,(H,6,7,8)

5-methylpyrimidin-2(1H)-one - Physico-chemical Properties

Molecular Formula	C5H6N2O
Molar Mass	110.11394
Density	1.22
Melting Point	211℃
Boling Point	309.1°C at 760 mmHg
Flash Point	140.8°C
Vapor Presure	0.000357mmHg at 25°C
Storage Condition	Room Temprature
Refractive Index	1.576

5-methylpyrimidin-2(1H)-one - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

5-methylpyrimidin-2(1H)-one - Introduction

5-methylpyrimidin-2(1H)-one is a chemical compound with the formula C5H6N2O. The following is an introduction to its nature, use, preparation and safety information:

Nature:
5-methylpyrimidin-2(1H)-one is a white crystalline powder with a distinctive odor. It has a melting point of about 159-163 degrees Celsius and is soluble in many organic solvents, such as ethanol, chloroform, and dimethyl sulfoxide. It is stable and does not react easily.

Use:
5-methylpyrimidin-2(1H)-one is an important organic synthesis intermediate, widely used in pharmaceutical, dye and pesticide industries. It can be used as a raw material for the synthesis of anticancer drugs, antibacterial drugs and antiviral drugs. In addition, it can also be used to synthesize pesticides, pigments and photosensitive materials.

Preparation Method:
There are many preparation methods of 5-methylpyrimidin-2(1H)-one. The common method is to synthesize 2-methylamino-5-methylpyrimidine by reacting with sodium hypochlorite. First, 2-methylamino-5-methylpyrimidine is reacted with acetaldehyde in the presence of sodium carbonate to give 2-mercapto-5-methylpyrimidine. 2-Mercapto-5-methylpyrimidine is then reacted with sodium hypochlorite to give the 5-methylpyrimidin-2(1H)-one product.

Safety Information:
5-methylpyrimidin-2(1H)-one has low toxicity, and the compound itself is less harmful to the human body under normal use conditions. However, like all chemicals, use and handle this compound with appropriate safety precautions, such as wearing chemical protective gloves and glasses, to prevent contact with the skin and eyes. During storage and handling, avoid contact with oxidants and ignition sources to avoid hazardous incidents. In the event of an accident, seek immediate medical assistance and provide information about the compound.

Last Update：2024-04-09 21:01:54