Name | Cortisone acetate |
Synonyms | Cortisone acetate 17,21-dihydroxypregn-4-ene-3,11,20-trione 11-dehydro-17-hydroxycorticosteroneacetate 4-PREGNEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE 11-dehydro-17-hydroxycorticosterone-21-acetate 17,21-dihydroxypregn-4-ene-3,11,20-trioneacetate 4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE ACETATE 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate 11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate 4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy- 17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE 21-ACETATE (8xi,9xi,14xi)-17-hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate (8alpha,9beta,14beta)-17-hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate |
CAS | 50-04-4 |
EINECS | 200-006-5 |
InChI | InChI=1/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21+,22+,23+/m1/s1 |
Molecular Formula | C23H30O6 |
Molar Mass | 402.48 |
Density | 1.26±0.1 g/cm3(Predicted) |
Melting Point | 237-240°C(lit.) |
Boling Point | 577.3±50.0 °C(Predicted) |
Specific Rotation(α) | D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane) |
Flash Point | 197.345°C |
Water Solubility | 19mg/L(25 ºC) |
Solubility | Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol. |
Vapor Presure | 0mmHg at 25°C |
Appearance | neat |
Color | White to Off-White |
Merck | 14,2539 |
BRN | 2067543 |
pKa | 12.32±0.60(Predicted) |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Refractive Index | 212 ° (C=1, MeOH) |
MDL | MFCD00003609 |
Physical and Chemical Properties | White needle crystal or crystalline powder (acetone), no smell. Stable in air. Mp239- 241 ℃, specific rotation [α]20D +164 °(0.5%, acetone), [α]23D +169 ° (chloroform), [Α] 25D +208 °-+217 ° (dioxane), ethanol solution of this product has maximum absorption at 240nm wavelength. Soluble in chloroform (1:4), soluble in acetone (1:75), slightly soluble in ethanol and ether, insoluble in water. This product is soluble in sulfuric acid yellow and no fluorescence (and hydrocortisone acetate phase difference). |
Use | For the treatment of low function of adrenal cortex, rheumatoid arthritis, rheumatism, lupus erythematosus and other diseases |
Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | GM9140000 |
HS Code | 32041200 |