50824-05-0
4-(Trifluoromethoxy)benzyl bromide
CAS: 50824-05-0
Molecular Formula: C8H6BrF3O
50824-05-0 - Names and Identifiers
| Name | 4-(Trifluoromethoxy)benzyl bromide |
| Synonyms | TIMTEC-BB SBB006578 4-(Trifluoromethoxy)benzyl P-TritluromethoxybenzylBromide 4-(Trifluoromethoxy)benzylbromide 4-(Trifluoromethoxy)benzyl bromide 4-Trifluoro methoxy benzyl bromide 4-(TRIFLUOROMETHOXY)BENZYL BROMIDE ALPHA-BROMO-4-(TRIFLUOROMETHOXY)TOLUENE 1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE [3,3,4,5,5,5-hexafluoro-4-(trifluoromethyl)pentyl] prop-2-enoate |
| CAS | 50824-05-0 |
| InChI | InChI=1/C9H7F9O2/c1-2-5(19)20-4-3-6(10,11)7(12,8(13,14)15)9(16,17)18/h2H,1,3-4H2 |
50824-05-0 - Physico-chemical Properties
| Molecular Formula | C8H6BrF3O |
| Molar Mass | 255.03 |
| Density | 1.594g/mLat 25°C(lit.) |
| Melting Point | 22-24°C |
| Boling Point | 82-84°C10mm Hg(lit.) |
| Flash Point | 202°F |
| Vapor Presure | 3.44mmHg at 25°C |
| Appearance | Liquid or Low Melting Solid |
| Specific Gravity | 1.594 |
| Color | Clear faintly yellow |
| BRN | 2521451 |
| Storage Condition | Refrigerated. |
| Sensitive | Lachrymatory |
| Refractive Index | n20/D 1.48(lit.) |
| Physical and Chemical Properties | Boiling Point: 82 - 84 at 10mm Hg density: 1.5838 flash point: 94 trait: tear substance |
50824-05-0 - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29093090 |
| Hazard Note | Corrosive/Lachrymatory |
| Hazard Class | 8 |
| Packing Group | III |
50824-05-0 - Reference Information
| application | 4-trifluoromethoxybenzyl bromide can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in the laboratory research and development process and chemical production process. |
| Preparation | At 0°C, slowly add phosphorus tribromide (0.5 ml) to a stirred 4-trifluoromethoxybenzyl alcohol (1 mmol) in a solution of ether (10 ml). Stir the reaction mixture for 0.5 hours. After the reaction is completed (TLC monitoring), the reaction mixture is poured into the ice water mixture and stirred for 1-2 hours. The aqueous phase was then extracted with ether. The combined organic layer was washed with NaHCO3 and water, and then washed with salt water. The combined organic layers were dried on Na2SO4 and the solvent was evaporated under reduced pressure. The method of using NBS as brominating reagent: slowly add triphenylphosphine to the solution of N-bromosuccinimide (NBS) in dichloromethane, stir continuously at 0 ℃ for 1 hour, reflux the obtained mixture at 60 ℃ for 15 minutes, then cool the reaction mixture to room temperature, and add 4-trifluoromethoxybenzyl alcohol to the cooled reaction mixture, the mixture was refluxed at 60°C for 30 minutes, the reaction mixture was concentrated, and then pumped dry to obtain the target product. |
Last Update：2024-04-09 21:04:16
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