50892-23-4
WY-14643
CAS: 50892-23-4
Molecular Formula: C14H14ClN3O2S
50892-23-4 - Names and Identifiers
50892-23-4 - Physico-chemical Properties
| Molecular Formula | C14H14ClN3O2S |
| Molar Mass | 323.8 |
| Density | 1.2984 (rough estimate) |
| Melting Point | 155°C |
| Boling Point | 514.4±50.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 40 mg/ml). |
| Appearance | White crystalline solid |
| Color | Off-white |
| pKa | 2.99±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. |
| Refractive Index | 1.5630 (estimate) |
| In vitro study | WY 14643 (10 μm) acts on aortic smooth muscle cells and almost completely inhibits IL-1 of the induced production of prostaglandins and cyclooxygenase-2 by inhibiting the NF-κB signaling pathway. WY14643 (250 μm) significantly reduced the expression level of TNF-α stimulated human endothelial cells by VCAM-1 and by 52%. Pretreatment of endothelial cells with WY 14643 (10 μm) followed by stimulation with TNF-α reduced U937 cell adhesion by 50%. |
| In vivo study | WY 14643 (1 mg/kg IV bolus) treatment of rats for 30 minutes resulted in left anterior descending occlusion after regional myocardial ischemia (25 minutes) and reperfusion (2 hours), infarct size was significantly reduced by ~ 44%. WY 14643(3 mg/kg) treatment of high-fat-fed rats reduced plasma glucose, triglycerides (-16% vs untreated group),Leptin(-52%), muscle triglyceride (-34%), total long chain acyl-CoA (LCACoAs)(-41%) levels. WY14643 significantly reduced visceral fat weight and total hepatic triglyceride content without increasing body weight. WY14643 enhances the sensitivity of the whole body to insulin. WY 14643 enhances the insulin-mediated index of muscle glucose metabolism (Rg') in red (47%) and White (63%) muscle, and in white adipose tissue (90%), and reduces the accumulation of triglycerides and lcacoas in muscle. |
50892-23-4 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R45 - May cause cancer R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | AG2915000 |
50892-23-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.088 ml | 15.442 ml | 30.883 ml |
| 5 mM | 0.618 ml | 3.088 ml | 6.177 ml |
| 10 mM | 0.309 ml | 1.544 ml | 3.088 ml |
| 5 mM | 0.062 ml | 0.309 ml | 0.618 ml |
Last Update：2024-01-02 23:10:35
50892-23-4 - Introduction
Nature:
-Appearance: The WY-14643 is a white solid.
-Solubility: WY-14643 has good solubility in organic solvents.
-Stability: The compound is stable under dry conditions, but may degrade under light and humid environments.
Use:
WY-14643 is a peroxisome proliferator-activated receptor alpha (PPAR) agonist. It can activate PPAR α in vivo, which is of great significance in regulating fatty acid oxidation, glucose metabolism and cholesterol metabolism. Therefore, WY-14643 is used in the study of lipid metabolism, liver diseases and obesity.
Preparation Method:
WY-14643 synthesis method is more complex, involving multi-step reaction. A common preparation method is to obtain an intermediate by reacting m-toluidine with 1,2-dichloro-4-pyrimidinone, and then sulfurizing to obtain the final product.
Safety Information:
-A detailed assessment of the safety of the WY-14643 is lacking. Due to its activity, it needs to be used with caution.
-During the operation, appropriate protective measures need to be taken, including wearing gloves, goggles and laboratory covers.
-The use and storage of this compound should be strictly controlled to avoid contact with skin, eyes, etc.
-Seek immediate medical help if inhaled or ingested.
Last Update：2024-04-09 21:04:16
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Product Name: WY-14643 Visit Supplier Webpage Request for quotationCAS: 50892-23-4
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Spot supply
Product Name: WY-14643 Visit Supplier Webpage Request for quotationCAS: 50892-23-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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