Name | 5-Hydroxymethyldeoxyuridine |
Synonyms | 5-HMdU 5-HYDROXYMETHYL-2'-D alpha-hydroxythymidine 5-hydroxymethyldeoxyuridine 5-Hydroxymethyldeoxyuridine 5-HYDROXYMETHYL-2'-DEOXYURIDINE 2'-deoxy-5-(hydroxymethyl)uridine 2'-deoxy-5-(hydroxymethyl)-uridin [(1S,9aR)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-yl]methanol |
CAS | 5116-24-5 |
EINECS | 225-848-0 |
Molecular Formula | C10H14N2O6 |
Molar Mass | 258.23 |
Density | 1.3598 (rough estimate) |
Melting Point | 176-179 °C |
Boling Point | 401.48°C (rough estimate) |
Solubility | DMSO (Slightly, Sonicated), Methanol (Slightly, Heated), Water (Slightly) |
Appearance | Solid |
Color | White to Off-White |
pKa | 9.01±0.10(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Stability | Hygroscopic |
Refractive Index | 1.5000 (estimate) |
Use | 5-Hydroxymethyldeoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM)。 |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | YU7600000 |
HS Code | 29349990 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.873 ml | 19.363 ml | 38.725 ml |
5 mM | 0.775 ml | 3.873 ml | 7.745 ml |
10 mM | 0.387 ml | 1.936 ml | 3.873 ml |
5 mM | 0.077 ml | 0.387 ml | 0.775 ml |