51630-33-2
VALERATE
CAS: 51630-33-2
Molecular Formula: C24H23ClO3
51630-33-2 - Names and Identifiers
51630-33-2 - Physico-chemical Properties
| Molecular Formula | C24H23ClO3 |
| Molar Mass | 394.89 |
| Density | 1.174±0.06 g/cm3(Predicted) |
| Boling Point | 495.1±35.0 °C(Predicted) |
| Physical and Chemical Properties | Yellow or brown oily liquid. B. p.248 ~ 250 ℃/266.4Pa, relative density 1.164(20 ℃), refractive index n20D1.5695. Soluble in general organic solvents, such as ethanol, acetone, toluene, xylene, etc.; insoluble in water. It is stable to light and heat, stable under acidic conditions, and decomposes in alkali. |
51630-33-2 - Risk and Safety
| Toxicity | LD50 orl-mus: >1 g/kg USXXAM #4062968 |
51630-33-2 - References
| toxicity | Acute oral LD50 in male rats was 2416mg/kg, mouse was 2129mg/kg; mouse acute percutaneous LD50>4766mg/kg. The non-effective dose in rats was 250mg/kg. Medium accumulation. There was no teratogenic and mutagenic effect in animal test. There was no significant irritation to skin and mucosa. |
| Use | pyrethroid insecticide, with the characteristics of high efficiency, safety, and strong Contact killing effect, as well as stomach poison and avoid the role of knock-down force is strong. It can control cotton aphid, cotton bollworm, corn borer, Spodoptera litura, rice leaf roller, rape aphid, diamondback moth, citrus leaf moth and health pests. Such as prevention and control of cotton bollworm, pink bollworm in the egg incubation period, young worms into the bud, Boll, with 20% emulsifiable concentrate 15~37.5/100m2 of water spray; For prevention and control of cotton aphid in adult, nymphs full-onset with 20% emulsifiable concentrate 15~37.5/100m2 on the water spray; Control of tea geometrid, tea moth, tea worm, with 20% emulsifiable concentrate 7.5~15mL/100 m2, spray on 10.5 ~ 15kg of water. The broad-spectrum insecticide with high efficiency, low toxicity and low residue has the effects of killing, gastric poison and repelling, quick knockdown of pests, strong toxicity and long duration. Suitable for the control of vegetables, fruit trees, tea, cotton, rice and other pests; Can also be used to control mosquitoes, cockroaches and other health pests. It can stimulate the growth of crops. |
| production method | in the presence of phase transfer catalyst and liquid alkali, P-chlorobenzyl cyanide reacts with bromoisopropane to form p-chlorophenyl isobutyronitrile, (R,S)-2-(p-chlorophenyl)-3-methylbutyric acid (pentanoic acid for short) was obtained by hydrolysis with 65% sulfuric acid. M-phenoxybenzaldehyde (referred to as the ether aldehyde) in the presence of liquid alkali, methanol, with phenoxybenzaldehyde (referred to as the ether aldehyde) in the presence of liquid alkali, methanol, the formation of M-phenoxybenzyl alcohol (ether alcohol). Pentanulinic acid is acylated with sulfoxide (or phosphorus trichloride) at 60% and then reacted with ether alcohol in petroleum ether to obtain valerate. preparation of α-isopropyl-p-chlorophenethylenitrile p-chlorophenylacetonitrile (93%)90g, 2-Bromopropane (96%)89g, triethyl-m-phenoxybenzylammonium chloride (60%)5G, after mixing with rapid stirring, 58±2 ml of 50% sodium hydroxide aqueous solution was added dropwise at <30 ℃, then the temperature was increased to () ℃, and the reaction was carried out for 8H. Then ml of toluene was added to collect the oil layer, the water layer was extracted with toluene, the oil layer was combined, and then washed with saturated brine until the washing water was neutral. The toluene was removed under reduced pressure and was ready for use without distillation, with a yield of 92%. Preparation of α-isopropyl-p-chlorophenylacetic acid 30g of α-isopropyl-p-chlorophenylacetonitrile (calculated as 100%) and 45ml of 65% sulfuric acid were heated at 144~147 ℃ for 8H, the reaction was cooled to 90 ° C., 50ml of toluene was added, stirred to room temperature, and transferred into a separatory funnel. The reaction flask was washed with 20ml of toluene, combined into a separatory funnel, and the aqueous layer was separated, the aqueous layer was extracted twice with toluene, and the toluene solution was combined. Then it was washed with saturated brine until the washing water was neutral. The pH value was adjusted to 8-9 with 10% NaOH, and the aqueous layer was separated and used for the next reaction without recrystallization from a solvent. The yield was 90%. Synthesis of valerate a white sodium salt was obtained by dehydrating an aqueous solution containing 30g of sodium α-isopropyl-p-chlorophenylacetate at 80~110 ℃ using a quaternary ammonium salt method, then add 62% triethyl M-phenoxybenzyl ammonium chloride 70~90g, dehydration reaction 4~6h, with 3% hydrochloric acid neutralization to slightly acidic, and then saturated salt water washing for many times, then wash once again, the water layer was separated and the toluene was removed under reduced pressure. The content was 80%, up to 7.2; The yield was over 80%, up to 92%. Acid chloride method of α-isopropyl-p-chlorophenylacetic acid and phosphorus trichloride, to generate the corresponding acid chloride, and then with M-phenoxybenzyl alcohol, to produce valerate. |
Last Update：2024-04-09 15:17:18
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CAS: 51630-33-2
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CAS: 51630-33-2
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Mobile: 18021002903
QQ: 3008007409
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