5176-22-7

5176-22-7 - Names and Identifiers

Name	1-azabicyclo[2.2.2]oct-3-ylmethanol
Synonyms	3-Quinuclidinemethanol Quinuclidin-3-ylMethanol 3-Hydroxymethylquinuclidine 1-azabicyclo[2.2.2]oct-3-ylmethanol 1-azabicyclo[2.2.2]octane-3-methanol 1-Azabicyclo[2.2.2]octane-3-methanol {1-azabicyclo[2.2.2]octan-3-yl}methanol 3-(Hydroxymethyl)-1-azabicyclo[2.2.2]octane
CAS	5176-22-7
InChI	InChI=1/C8H15NO/c10-6-8-5-9-3-1-7(8)2-4-9/h7-8,10H,1-6H2

5176-22-7 - Physico-chemical Properties

Molecular Formula	C8H15NO
Molar Mass	141.21
Density	1.096g/cm³
Boling Point	114-115℃
Flash Point	81.109°C
Vapor Presure	0.075mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.539

5176-22-7 - Introduction

1-azabicyclo[2.2.2]oct-3-ylmethanol(1-azabicyclo[2.2.2]oct-3-ylmethanol), also known as 3-hydroxymethyl-8-epoxyquinoline ([3.2.1]octane), is an organic compound.

The properties of this compound are as follows:
-Appearance: colorless or yellowish liquid
-Molecular formula: C9H17NO2
-Molecular weight: 171.24g/mol
-Melting point:-12°C
-Boiling Point: 166-168°C
-Solubility: Soluble in water and organic solvents such as ethers and alcohols

1-azabicyclo[2.2.2]oct-3-ylmethanol have a variety of uses, including:
-Drug synthesis intermediate: It can be used to synthesize drugs with a ring structure of three carbon atoms, such as Israel ring, tetracycline, quinine and atropine.
-Pesticide synthesis: It can be used to synthesize certain pesticides and fungicides.
-Photoinitiator: It can be used as a photoinitiator for polymerization and photocuring.

1-azabicyclo[2.2.2] The preparation of oct-3-ylmethanol is usually carried out by the following steps:
1. The methyl dehydrogenated alcohol is reacted with sodium hydroxide at low temperature to obtain the corresponding olefin.
2. Olefins are reacted with peroxides similar to hydrogen peroxide or peroxide to generate epoxy compounds.
3. Epoxy compounds react with sodium bisulfite or potassium bisulfite to open the ring to generate the corresponding alcohols.

Note the following safety information when using the 1-azabicyclo[2.2.2]oct-3-ylmethanol:
- 1-azabicyclo[2.2.2]oct-3-ylmethanol may cause eye, skin and respiratory tract irritation. Therefore, contact with the eyes, skin and respiratory tract should be avoided during the operation. In case of inadvertent contact, flush immediately with plenty of water and seek medical attention if necessary.
-Provide good ventilation during operation to avoid inhalation of gas or steam.
-When storing and handling, it should be kept in a closed container and away from fire and oxidizing agents.
-When disposing of waste, follow local environmental regulations and avoid discharging it into water bodies or the environment.

Last Update：2024-04-09 20:48:19