5189-11-7

Name	malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1)
Synonyms	225-970-4 sanomtgran Sandomigran PIZOTIFEN MALATE Pizotifan Malate Einecs 225-970-4 Pizotifen malate PIZOTYLINE MALATE sandomygranmalate 4-(9,10-DIHYDRO-1-THIA-BENZO[F]AZULEN-4-YLIDENE)-1-METHYL-PIPERIDINE, COMPOUND WITH 2-HYDROXY-SUCCINIC ACID
CAS	5189-11-7
EINECS	225-970-4
InChI	InChI=1/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9)

Molecular Formula	C23H27NO5S
Molar Mass	429.53
Melting Point	185-186° (dec)
Boling Point	436.7°C at 760 mmHg
Flash Point	217.9°C
Solubility	Aqueous Acid (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	7.92E-08mmHg at 25°C
Appearance	Solid
Color	White to Off-White
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Stability	Hygroscopic
In vitro study	Pizotifen malate (BC-105 malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Pizotifen is an antidepresent 5-HT 2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.
In vivo study	The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection

Last Update：2024-01-02 23:10:35

biological activity	Pizotifen Malate (BC-105) is used to treat frequent migraine.
use	this product is an antihistamine drug used to treat migraine

Last Update：2024-04-10 22:29:15

Product Name: malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1) Request for quotation
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5189-11-7

5189-11-7 Request for Quotation