5198-87-8
2-Chloro-1,3-thiazole-4-carboxylic acid
CAS: 5198-87-8
Molecular Formula: C4H2ClNO2S
5198-87-8 - Names and Identifiers
| Name | 2-Chloro-1,3-thiazole-4-carboxylic acid |
| Synonyms | 4-Carboxy-2-chloro-1,3-thiazole 2-Chlorothiazole-4-carboxylic acid 2-Chloro-4-thiazolecarboxylic acid 4-Thiazolecarboxylic acid, 2-chloro- 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-Chloro-1,3-thiazole-4-carboxylic acid 2-Chlorothiazole-4-Carboxylic Acid(WXC02298) |
| CAS | 5198-87-8 |
| InChI | InChI=1/C4H2ClNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8) |
| InChIKey | UVYJJJQMZPCYKY-UHFFFAOYSA-N |
5198-87-8 - Physico-chemical Properties
| Molecular Formula | C4H2ClNO2S |
| Molar Mass | 163.58 |
| Density | 1.693±0.06 g/cm3(Predicted) |
| Melting Point | 220 °C |
| Boling Point | 370.2±34.0 °C(Predicted) |
| Flash Point | 177.696°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White to yellow |
| pKa | 3.15±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.634 |
5198-87-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
5198-87-8 - Introduction
2-Chloro-1,3-thiazole-4-carboxylic acid is an organic compound with the molecular formula C4H3ClN2O2S and a thiazole ring and carboxylic acid functional group in the structure. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-Chloro-1,3-thiazole-4-carboxylic acid is white to light yellow crystal.
-Melting point: about 150-153 degrees Celsius.
-Solubility: 2-Chloro-1,3-thiazole-4-carboxylic acid has good solubility in common organic solvents, such as alcohols, ethers and esters, but has low solubility in water.
-chemical properties: 2-Chloro-1,3-thiazole-4-carboxylic acid can react with other compounds, such as reacting with amines to generate corresponding amides, nucleophilic addition reactions with nucleophiles, etc.
Use:
-Pharmaceutical intermediates: 2-Chloro-1,3-thiazole-4-carboxylic acid, as pharmaceutical intermediates, is widely used in the pharmaceutical field and can be used to synthesize some biologically active compounds.
-Pesticide intermediates: 2-Chloro-1,3-thiazole-4-carboxylic acid can also be used as pesticide intermediates for the synthesis of pesticide products.
-Other uses: In addition, 2-Chloro-1,3-thiazole-4-carboxylic acid can also be used as chemical reagents and catalysts.
Preparation Method:
The preparation method of 2-Chloro-1,3-thiazole-4-carboxylic acid is usually carried out by the following steps:
1. react 2-chloro -4-thiazolecarbonyl chloride (n) with alkali (such as sodium carbonate) or alkaline medium (such as sodium hydroxide) to generate 2-Chloro-1,3-thiazole-4-carboxylic acid sodium (n).
2.2-Chloro-1,3-thiazole-4-carboxylic acid sodium is reacted with dilute acid (such as dilute hydrochloric acid) to give 2-Chloro-1,3-thiazole-4-carboxylic acid.
Safety Information:
2-Chloro-1,3-thiazole-4-carboxylic acid belongs to organochlorine compounds, which have certain toxicity and should be paid attention to safe operation. The following safety measures shall be observed during use and storage:
-Avoid contact with skin and eyes, and wear appropriate protective equipment (such as gloves and goggles).
-Operate in a well-ventilated environment to avoid inhaling its vapor or dust.
-Store in a cool, dry, ventilated place, away from fire and oxidizing agents.
-Avoid reacting with strong oxidants to avoid unsafe situations.
When dealing with 2-Chloro-1,3-thiazole-4-carboxylic acid, it is best to follow relevant regulations and safety operation guidelines, and consult chemical experts when necessary.
Nature:
-Appearance: 2-Chloro-1,3-thiazole-4-carboxylic acid is white to light yellow crystal.
-Melting point: about 150-153 degrees Celsius.
-Solubility: 2-Chloro-1,3-thiazole-4-carboxylic acid has good solubility in common organic solvents, such as alcohols, ethers and esters, but has low solubility in water.
-chemical properties: 2-Chloro-1,3-thiazole-4-carboxylic acid can react with other compounds, such as reacting with amines to generate corresponding amides, nucleophilic addition reactions with nucleophiles, etc.
Use:
-Pharmaceutical intermediates: 2-Chloro-1,3-thiazole-4-carboxylic acid, as pharmaceutical intermediates, is widely used in the pharmaceutical field and can be used to synthesize some biologically active compounds.
-Pesticide intermediates: 2-Chloro-1,3-thiazole-4-carboxylic acid can also be used as pesticide intermediates for the synthesis of pesticide products.
-Other uses: In addition, 2-Chloro-1,3-thiazole-4-carboxylic acid can also be used as chemical reagents and catalysts.
Preparation Method:
The preparation method of 2-Chloro-1,3-thiazole-4-carboxylic acid is usually carried out by the following steps:
1. react 2-chloro -4-thiazolecarbonyl chloride (n) with alkali (such as sodium carbonate) or alkaline medium (such as sodium hydroxide) to generate 2-Chloro-1,3-thiazole-4-carboxylic acid sodium (n).
2.2-Chloro-1,3-thiazole-4-carboxylic acid sodium is reacted with dilute acid (such as dilute hydrochloric acid) to give 2-Chloro-1,3-thiazole-4-carboxylic acid.
Safety Information:
2-Chloro-1,3-thiazole-4-carboxylic acid belongs to organochlorine compounds, which have certain toxicity and should be paid attention to safe operation. The following safety measures shall be observed during use and storage:
-Avoid contact with skin and eyes, and wear appropriate protective equipment (such as gloves and goggles).
-Operate in a well-ventilated environment to avoid inhaling its vapor or dust.
-Store in a cool, dry, ventilated place, away from fire and oxidizing agents.
-Avoid reacting with strong oxidants to avoid unsafe situations.
When dealing with 2-Chloro-1,3-thiazole-4-carboxylic acid, it is best to follow relevant regulations and safety operation guidelines, and consult chemical experts when necessary.
Last Update：2024-04-09 21:32:42
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Product Name: 2-chlorothiazole-4-carboxylic acid Visit Supplier Webpage Request for quotationCAS: 5198-87-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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Product Name: 2-Chloro-thiazole-4-carboxylic acid Visit Supplier Webpage Request for quotation
CAS: 5198-87-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 5198-87-8
Tel: 18301782025
Email: 3008007409@qq.com
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QQ: 3008007409
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