52029-86-4
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid
CAS: 52029-86-4
Molecular Formula: C19H10N2O3
52029-86-4 - Names and Identifiers
52029-86-4 - Physico-chemical Properties
| Molecular Formula | C19H10N2O3 |
| Molar Mass | 314.29 |
| Density | 1.54±0.1 g/cm3(Predicted) |
| Melting Point | >300°C |
| Boling Point | 716.9±62.0 °C(Predicted) |
| Solubility | DMSO: 15mg/mL at≥60°C |
| Appearance | solid |
| pKa | 2.65±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | STO-609 inhibited the activity of recombinant CaM-KKα and CaM-KKβ with Ki values of 80 ng/ml and 15 ng/ml, respectively, and STO-609 also inhibited their autophosphorylation activity. STO-609 is highly selective for CaM-KK and has no significant effect on its downstream CaM Kinase (CaM-KI and -IV). In transfected Hela cells, STO-609 inhibited Ca in a dose-dependent manner. |
| In vivo study | Administration to adult mice in vivo, STO-609 will cause the increase of osteoblasts, osteoclast reduction, the ovariectomy induced osteoporosis has a protective effect. Intracerebroventricular injection of STO-609 did not affect the negative regulatory response to neurohypoglycemia or the activation of AMPK by hypoglycemia. |
52029-86-4 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
52029-86-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.182 ml | 15.909 ml | 31.818 ml |
| 5 mM | 0.636 ml | 3.182 ml | 6.364 ml |
| 10 mM | 0.318 ml | 1.591 ml | 3.182 ml |
| 5 mM | 0.064 ml | 0.318 ml | 0.636 ml |
Last Update：2024-01-02 23:10:35
52029-86-4 - Reference Information
| biological activity | STO-609 is a specific CaM-KK inhibitor that inhibits the activity of CaM-KKα and CaM-KKβ, ki values were 80 ng/ml and 15 ng/ml, respectively, and inhibited its autophosphorylation activity. STO-609 can inhibit AMPK activity and inhibit autophagy. |
| Target | TargetValue AMPK () CaM-KKβ (Cell-free assay) 47 nM(Ki) caM-KKα (Cell-free assay) 0.25 μm (Ki) |
| Target | Value |
| AMPK () | |
| CaM-KKβ (Cell-free assay) | 47 nM(Ki) |
| CaM-KKα (Cell-free assay) | 0.25 μM(Ki) |
| in vitro study | STO-609 inhibits the activity of recombinant CaM-KKα and CaM-KKβ, ki values were 80 ng/ml and 15 ng/ml, respectively, and STO-609 also inhibited their autophosphorylation activity. STO-609 is highly selective for CaM-KK and has no significant effect on its downstream CaM Kinase (CaM-KI and -IV). In transfected Hela cells, STO-609 inhibited Ca in a dose-dependent manner. |
| in vivo study | in vivo administration to adult mice, STO-609 can cause the increase of osteoblasts and the decrease of osteoclasts, it has a protective effect on osteoporosis caused by ovariectomy. Intracerebroventricular injection of STO-609 did not affect the negative regulatory response to neurohypoglycemia or the activation of AMPK by hypoglycemia. |
| Use | a specific CaM-KK inhibitor that inhibits both CaM-KKα and CaM-KKβ, ki values were 80ng/ml and 15ng/ml, respectively, and inhibited its autophosphorylation activity. STO-609 is a specific inhibitor of the Ca(2 )/calmodulin-dependent protein kinase kinase. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K( I) values of 80 and 15 ng/ml, respectively and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC(50) value of the compound against CaM-KII is approximately 10 microg/ml. STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro. |
Last Update：2024-04-09 20:49:11
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Spot supply
Product Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid Visit Supplier Webpage Request for quotationCAS: 52029-86-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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