523-87-5
dimenhydrinate
CAS: 523-87-5
Molecular Formula: C17H21NO.C7H7ClN4O2
523-87-5 - Names and Identifiers
| Name | dimenhydrinate |
| Synonyms | DRAMAMINE THEOHYDRAMINE DIMENHYDRINATE dimenhydrinate diphenhydramine 8-chlorotheophyllinate 2-(benzhydryloxy)-n,n-dimethylethylamine 8-chlorotheophyllinate 2-(diphenylmethoxy)-n,n-dimethylethylamine8-chlorotheophyllinate 2-(benzhydryloxy)-n,n-dimethylethylaminecompd.with8-chlorotheophylline N-[2-DIPHENYLMETHOXYETHYL]-N,N-DIMETHYLAMMONIUM 8-CHLORO-THEOPHYLLINATE 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2-oxo-2,3-dihydro-1H-purin-6-olate |
| CAS | 523-87-5 |
| EINECS | 208-350-8 |
| InChI | InChI=1/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;13H,1-2H3 |
| InChIKey | NFLLKCVHYJRNRH-UHFFFAOYSA-N |
523-87-5 - Physico-chemical Properties
| Molecular Formula | C17H21NO.C7H7ClN4O2 |
| Molar Mass | 469.97 |
| Density | 1.2586 (rough estimate) |
| Melting Point | 102-107°C |
| Boling Point | 343.7°C at 760 mmHg |
| Flash Point | 101.5°C |
| Water Solubility | Slightly soluble (0.1-1 g/100 mL at 22 ºC) |
| Solubility | Slightly soluble in water, freely soluble in ethanol (96 per cent). |
| Vapor Presure | 6.9E-05mmHg at 25°C |
| Appearance | White powder |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Hygroscopic |
| Refractive Index | 1.6500 (estimate) |
| Use | Suitable for motion sickness, pregnancy, radiation therapy, after surgery caused by Nausea, Vomit, Vertigo |
523-87-5 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R61 - May cause harm to the unborn child R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S53 - Avoid exposure - obtain special instructions before use. |
| WGK Germany | 3 |
| RTECS | XH5082000 |
| TSCA | Yes |
| HS Code | 2939590000 |
523-87-5 - Standard
Authoritative Data Verified Data
This product is 1, 3-dimethyl-8-chloro-3, 7-dihydro-1h-purin-2, 6-dione and N, n-dimethyl-2-(diphenylmethoxy) ethylamine (1:1). Diphenhydramine (C17H21NO) should be 53.0% ~ 55.5% and 8-chlorotheophylline (C7H7C1N402) should be 44.0% ~ 47.0% based on the dry product.
Last Update：2024-01-02 23:10:35
523-87-5 - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in ethanol or chloroform, and slightly soluble in water or ether.
melting point
The melting point of this product (General 0612) is 102~107°C.
Last Update：2022-01-01 13:38:34
523-87-5 - Differential diagnosis
Authoritative Data Verified Data
- take 0.lg of this product, add lml of hydrochloric acid and 0.lg of potassium chlorate, put it on a water bath to evaporate, and add several drops of ammonia test solution, which shows purple-red color.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 271).
Last Update：2022-01-01 13:38:34
523-87-5 - Exam
Authoritative Data Verified Data
chloride
take 0.30g of this product, put it in a 200ml measuring flask, add 50ml of water, 3ml of ammonia test solution and 6mL of 10% ammonium nitrate solution, put it on a water bath and heat it for 5 minutes, add 25ml of silver nitrate test solution, shake it well, then heat on the water bath for 15 minutes, shake and cool constantly, dilute to the scale with water, shake well, place for 15 minutes, filter, take 25ml of filtrate and put it in 50ml Nessler's colorimetric tube, add 10ml of dilute nitric acid, dilute with water to 50ml, shake well, place in the dark for 5 minutes, check according to law (General rule 0801), and compare with the control solution made of ML of standard sodium chloride solution, no more concentrated (0.04%).
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing 0.4mg of tea benzene and Hamming per 1 ml, as a test solution; Take appropriate amount with precision, A solution containing 6ug of tea-benzene-Hamming per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. According to the method of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane was used as the filler, methanol-triethylamine buffer (1:1) was used as the mobile phase, and the detection wavelength was 225nm. Take theophylline and tea-benzene-Hamming, add mobile phase to dissolve and dilute to make solution containing about 20ug in each lml, take 10u1 to inject human liquid chromatograph, record chromatogram, peak order is theophylline, the theoretical plate number of 8-chlorotheophylline and diphenhydramine shall not be less than 2000 based on the peak of diphenhydramine. The separation degree of theophylline peak and 8-chlorotheophylline peak shall meet the requirements. 10 u1 of the test solution and the control solution were respectively injected with human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of diphenhydramine peak; if there are impurity peaks in the chromatogram of the test solution, the peak area of theophylline shall not be greater than 0.75 times of the peak area of 8-chlorophylline in the control solution, the sum of the peak areas of each impurity shall not be greater than the peak area of 8-chlorophylline in the control solution.
loss on drying
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure to constant weight. The weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 13:38:35
523-87-5 - Content determination
Authoritative Data Verified Data
diphenhydramine
take this product about 0.3g, precision weighing, add glacial acetic acid 15ml, slightly warm to dissolve, cool, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 25.54mg of C17H21NO.
8-chlorophylline
take 0.3g of this product, accurately weigh it, put it in a 200ml measuring flask, add 50ml of water, 3ml of ammonia test solution and 6mL of 10% ammonium nitrate solution, and heat it on a water bath for 5 minutes, precision Plus silver nitrate titration solution (0.lmol/L)25ml, shake well, then heat on the water bath for 15 minutes, shake constantly, cool, dilute to the scale with water, shake well, place for 15 minutes, filter, take a precise amount of continuous filtrate 100ml, add nitric acid to make it acidic, then add 3ml of nitric acid and ammonium ferric sulfate indicator solution 2ml, and use ammonium thiocyanate titration solution (0.lmol/L) titration. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 21.46mg of C7H7C1N402.
Last Update：2022-01-01 13:38:36
523-87-5 - Category
Authoritative Data Verified Data
antihistamines.
Last Update：2022-01-01 13:38:36
523-87-5 - Storage
Authoritative Data Verified Data
sealed and stored in a dry place.
Last Update：2022-01-01 13:38:36
523-87-5 - Dimenhydrinate Tablets
Authoritative Data Verified Data
This product contains 90.0% ~ 110.0% of the labeled amount of tea-benzene-Hamming (C24H28ClN503), and contains 43.4% ~ 47.9% of the content of 8-chlorophylline (C7H7C1N402).
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (about 0.4g of tea-benzene-Hamming), add 40ml of ethanol at a slight temperature, grind, filter, and evaporate the filtrate to dryness, identification (1) Test under the item of tea and benzene, showed the same reaction.
- in the chromatogram recorded under the content determination item, the retention time of the two main peaks of the test solution should be consistent with the retention time of the corresponding two main peaks of the control solution.
examination
- The test solution under the content determination item is taken as the test solution; The appropriate amount is taken for the precise amount, as a control solution, a solution containing about 6ug of tea-benzene-Hamming per 1 ml was prepared by quantitative dilution with mobile phase. Method for the determination of related substances of phenhydramine in illuminated tea. If there are impurity peaks in the chromatogram of the test solution, the peak area of theophylline shall not be greater than 0.75 times of the peak area of 8-chlorophylline in the control solution, the sum of the peak areas of each impurity shall not be greater than the peak area of 8-chlorophylline in the control solution.
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, after 45 minutes, take 10ml of the solution, filter, Take 5ml of the filtrate, put it in a 20ml measuring flask (50mg specification) or a 10ml measuring flask (25mg specification), dilute it to the scale with water, and shake it well, measure absorbance at 278nm wavelength according to UV-visible spectrophotometry (General rule 0401); Take another pair of tea-benzene-Hamming, water was added to dissolve and quantitatively diluted to prepare a solution containing about 14ug per 1 ml, which was determined by the same method, and the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under The tablet item, General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-triethylamine buffer (1:1) as mobile phase; The detection wavelength was 225nm. Take theophylline and hedylamine, add mobile phase to dissolve and dilute to make solution containing about 20ug in each lml, take 10ul injection liquid chromatograph, record chromatogram, peak order is theophylline, the theoretical plate number of 8-chlorotheophylline and diphenhydramine shall not be less than 2000 based on the peak of diphenhydramine. The separation degree of theophylline peak and 8-chlorotheophylline peak shall meet the requirements.
- determination Method: Take 20 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about 40mg equivalent to 40mg of tea and benzene), put it in a 100ml measuring flask, and add appropriate amount of mobile phase, dissolve by ultrasound, dilute to scale with mobile phase, shake well, filter, take filtrate as test solution, take 10u1 and inject HPLC with precision, record chromatogram; another reference product of tea-benzene-Hamming was precision weighed, dissolved and quantitatively diluted with mobile phase to make a solution containing about 0.4mg per 1 ml, which was determined by the same method. According to the external standard method, the contents of tea-benzene-Hamming and 8-chlorine-tea-alkali were calculated by peak area.
category
The same as tea, benzene and Hamming.
specification
(l)25mg (2)50mg
storage
sealed and stored in a dry place.
Last Update：2022-01-01 13:38:37
523-87-5 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| anti-motion sickness | tea diphenhydramine is a double salt of diphenhydramine and 8-chlorophylline. The anti-histamine effect is weaker than diphenhydramine, and the anti-motion sickness and anti-emetic effect is stronger. It is mainly used to prevent nausea, vomiting, vertigo and Menier syndrome caused by motion sickness. It is also effective for various vertigo and vomiting caused by radiation therapy, pregnancy, surgery, internal otitis and the use of drugs (such as streptomycin). |
| properties | tea benzohydrin is a white transparent crystalline powder, odorless, slightly soluble in water and easily soluble in ethanol. |
| Effect | is the double salt of diphenhydramine and 8-chlorophylline. The effect is the same as diphenhydramine hydrochloride, but its antihistamine effect is weaker than the latter. It can inhibit the chemosensory area of the brain, and has general central inhibition and anticholinergic effects, thus having sedative and antiemetic effects. After oral administration, the absorption is rapid and complete, takes effect in 15-60 minutes, the effect can last for 3-6 hours, the elimination phase half-life (t1/2 β) is 4-6 hours, and the plasma protein binding rate is high. It is mainly metabolized in the liver and excreted in the urine in the form of metabolites. Patients with liver insufficiency taking this product can accumulate in the body and should be reduced. |
| drug interaction | 1. do not drink alcohol or take with other central nervous system suppressive drugs after taking medicine. 2. This product can increase the efficiency of ethanol, central nervous system inhibitors, tricyclic antidepressants, etc. It can temporarily affect the absorption of barbiturates and sulfamethamide sodium; when used with sodium p-aminosalicylate, the blood concentration of the latter is reduced. 3. Take it with food or milk to reduce the irritation of the stomach. |
| precautions | 1. those who are allergic to this product and other ethanolamine drugs, newborns and premature infants are prohibited. 2. Pregnant women take this medicine within the first 4 months of pregnancy, the incidence of fetal congenital cardiovascular abnormalities and inguinal hernia may increase, and the relationship with medication has yet to be confirmed. It should not be taken at the beginning of pregnancy. 3. The antiemetic effect of this product can add difficulties to the diagnosis of appendicitis and drug-induced reactions. 4. Sleepiness, inattention, etc. may occur after medication. It is not suitable to drive cars, boats, etc., and it is not suitable to engage in difficult and dangerous machine operations. |
| adverse reactions | low toxicity, large doses can cause drowsiness and occasionally rash. Long-term use may cause diseases of the hematopoietic system. (2015-10-23) |
| use | motion sickness medicine suitable for nausea, vomiting, vertigo, etc. caused by motion sickness, pregnancy, radiotherapy, surgery, etc. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:09
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Product Name: dimenhydrinate Request for quotation
CAS: 523-87-5
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CAS: 523-87-5
Tel: 0086-551-65418684
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Mobile: 0086 189 4982 3763
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Product Name: Dimenhydrinate Visit Supplier Webpage Request for quotationCAS: 523-87-5
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