5250-39-5
Flucloxacillin
CAS: 5250-39-5
Molecular Formula: C19H17ClFN3O5S
5250-39-5 - Names and Identifiers
5250-39-5 - Physico-chemical Properties
| Molecular Formula | C19H17ClFN3O5S |
| Molar Mass | 453.87 |
| Density | 1.59±0.1 g/cm3(Predicted) |
| Boling Point | 677.3±55.0 °C(Predicted) |
| Storage Condition | 2-8°C |
5250-39-5 - Pharmacokinetics of Flucloxacillin sodium for injection
from VIP
Author:
Zheng Heng , Li Hongmei , Fang Shuxian
Abstract:
Objective: to establish an HPLC method for the determination of Flucloxacillin sodium in human plasma and to study the pharmacokinetics of Flucloxacillin sodium in healthy volunteers. Methods: A single-dose single-cycle dosing regimen was designed to determine the plasma concentration of Flucloxacillin sodium for injection in 12 healthy subjects at different time points. Results: the pharmacokinetic parameters tmax and Cmax were (0.75±0.11)h and (138.4±17.8)mg after a single dose of G Flucloxacillin sodium. L-1,AUC0-10 (260.0±48.7)mg.h. On L-1,AUC0-∞ was (271.6±49.6)mg.h.L-1, the estimated t1/2α was (0.42±0.37)h,t1/2β was (1.7±1.2)h, and the clearance (CL) was (3.8±0.9)L.h-1. The tmax and Cmax of 6 healthy male subjects were (0.79±0.1) h and (129.0±17.7)mg.L-1,AUC0-10 (238.6±54.1)mg.h. On L-1,AUC0-∞ was (248.1±53.6)mg.h. On L-1, the estimated t1/2α was (0.35±0.42)h,t1/2β was (1.2±0.4)h, and the clearance rate (CL) was (4.2±0.4). tmax and Cmax were (0.71±0.1)h and (147.9±12.4)mg in L.L-1.6 female healthy subjects, respectively. L-1,AUC0-10 (281.4±34.6)mg.h. On L-1,AUC0-∞ was (295.1±5.0)mg.h.L-1, The estimated t1/2α was (2.1±1.5)h,t1/2β was (2.1±1.5)h, and the clearance (CL) was (3.4±0.5)L.h-1. Conclusion: The double one-side t-test analysis showed that Flucloxacillin sodium injection in male and female healthy subjects tmax,Cmax,AUC0-10,AUC0-∞ and t1/2,tmax is similar (P0.05), there was no gender difference.expand
Key words:
Flucloxacillin sodium injection high performance liquid chromatography pharmacokinetics
DOI:
10.3321/j.issn:1001-5213.2007.02.025
cited:
year:
2007
Last Update：2024-01-02 23:10:35
5250-39-5 - Determination of flucloxacillin in human plasma by liquid chromatography-tandem mass spectrometry
from hownet
Author:
Bi yue , Hu Yanling , Sun Lu , trifoff
Abstract:
objective to provide reference for clinical safe and effective dosage regimen. Methods liquid chromatography-tandem mass spectrometry (LC-MS-MS) was used. Plasma samples were treated by liquid-liquid extraction, using acetonitrile-water (volume ratio 25:75) as mobile phase and Zorbax Eclipse XDB C8 column (150mm × 4.6, 5 μm). Separation; By electrospray triple quadrupole tandem mass spectrometry, negative ions, selected reaction monitoring mode for detection, for quantitative ion reaction were m/z452 & rarr;m/z 311 (flucloxacillin) and m/z 468 & rarr;m/z 327 (internal standard dicloxacillin). Results the linear range of flucloxacillin was 20.0~15000 μg · L ^-1, the limit of quantification was 20.0 μg · L ^-1, the recovery rate was more than 70%, the inter-day precision was less than 7%. Conclusion The method is suitable for the pharmacokinetic study of Flucloxacillin sodium for injection by single intramuscular injection.
Key words:
Flucloxacillin sodium; liquid chromatography-tandem mass spectrometry; Pharmacokinetics
DOI:
CNKI:SUN:SYYD.0.2009-05-014
cited:
year:
2009
Last Update：2023-08-16 22:09:50
5250-39-5 - Flucloxacillin sodium for injection in bottled dosage form
from Baidu Library
Application (patent) number:
CN201721172065.X
application date:
2017-09-13
Public/Announcement Number:
CN209004702U
Public/announcement date:
2019.06.21
applicant (patent):
Shanxi Zhendong Taisheng Pharmaceutical Co., Ltd.
inventor:
Gao Zhi-Hua , Liu Jinrong , Zhao Yongjun , Shen Da
National and provincial code:
CN140202
Abstract:
The utility model discloses a Flucloxacillin sodium for injection bottled dosage form, belonging to the technical field of pharmaceutical packaging, including a bottle body, the bottle body is used to contain a predetermined dose of Flucloxacillin sodium powder, one end of the bottle body is provided with an inwardly recessed hollow conical interface; And also includes a soft bin arranged on the bottle body, the soft bin is used to contain a predetermined dose of solvent, the soft bin includes an arc-shaped top surface and a conical bottom surface for sealing connection; The arc-shaped top surface protrudes outside the bottle body; The conical bottom surface is sealed and connected with the inner wall of the conical interface, and the tip of the conical bottom surface extends from the conical interface into the bottle body. The solvent and air in the soft bin are pressed against the conical bottom surface by extruding the arc-shaped top surface. After the tip of the conical bottom surface is broken, the solvent in the soft bin flows into the bottle, after shaking and mixing, the liquid medicine can be prepared into a preset concentration. Since the dose of the powder and the solvent is preset, the concentration of the prepared liquid medicine is more accurate, and the accuracy of the preparation of the liquid medicine is effectively improved, more conducive to the efficacy of the play.
Last Update：2023-08-16 22:09:50
5250-39-5 - Flucloxacillin sodium taste-masked particles and preparation method thereof
from Palm Bridge research
Application (patent) number:
CN201610235145.9
application date:
2016-04-15
Public/Announcement Number:
CN105816431A
Public/announcement date:
2016.08.03
applicant (patent):
Zhejiang Jutai Pharmaceutical Co., Ltd.; Yousheng Mette Pharmaceutical Co., Ltd.; Shanxi Yousheng Mette Pharmaceutical Co., Ltd.
inventor:
Yi Jianyong , Zhu fangmeng , can Zhao select , he Yanhua
National and provincial code:
CN330802
Abstract:
The invention discloses a kind of taste masking particles and its preparation method, especially relates to a kind of strong bitter taste, high dosage, water soluble drugs (such as Flucloxacillin sodium) the invention relates to a taste masking method for making particles, which belongs to the technical field of medicine. It is used to solve the masking of the bitter taste of the drug, maintain or improve the water solubility of the drug, and improve its stability, so as to improve the compliance of clinical patients. The taste masking particles of Flucloxacillin sodium include a main drug and a pharmaceutical excipient, and the taste masking particles are dissolved or highly dispersed in a carrier solution by the main drug, and then the particles are made by a conventional granulation method, the ratio of the carrier to the main drug is 25 ~ 200%; The carrier is a polymer material with film-forming property and good water solubility. The carrier solution medium is water or a certain concentration of ethanol solution. The main drug Flucloxacillin sodium as the representative of a strong bitter taste, clinical use of high dose, high water-soluble drugs.
Last Update：2023-08-16 22:09:50
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