528-48-3
Fisetin
CAS: 528-48-3
Molecular Formula: C15H10O6
528-48-3 - Names and Identifiers
| Name | Fisetin |
| Synonyms | fustet fustel Fisetin fisetholz C.I. 75620 superfustel superfustelk jungerfustik ungarischesgelbholz C.I. Natural Brown 1 3,3,4,7-Tetrahydroxyflavone 3,7,3',4'-TETRAHYDROXYFLAVONE 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one |
| CAS | 528-48-3 |
| EINECS | 208-434-4 |
| InChI | InChI=1/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H |
528-48-3 - Physico-chemical Properties
| Molecular Formula | C15H10O6 |
| Molar Mass | 286.24 |
| Density | 1.2981 (rough estimate) |
| Melting Point | >330°C(lit.) |
| Boling Point | 348.61°C (rough estimate) |
| Flash Point | 233°C |
| Solubility | Soluble in ethanol, acetone and acetic acid. Almost insoluble in water, ether, benzene, chloroform and petroleum ether. |
| Vapor Presure | 3.23E-15mmHg at 25°C |
| Appearance | Yellow needle crystal (dilute ethanol) |
| Color | Pale Yellow to Very Dark Yellow |
| Merck | 14,4088 |
| BRN | 292829 |
| pKa | 6.83±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.4413 (estimate) |
| MDL | MFCD00006829 |
| Physical and Chemical Properties | Soluble in ethanol, acetone and acetic acid. Almost insoluble in water, ether, benzene, chloroform and petroleum ether. It is derived from the plants such as wood and tree Rhus suce Danea L Wood |
528-48-3 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | LK9250000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29329990 |
528-48-3 - Reference
| Reference Show more | 1. Jia, QingLing, et al. "Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264. 7 macrophage-derived foam cells." European journal of pharmacology 865 (2019): 172748.https://doi.org/10.1016/j.ejphar.2019.172748 2. Lyu, Yunbin, et al. "Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai." Biochemical Engineering Journal 163 (2020): 107759.https://doi.org/10.1016/j.bej.2020.107759 3. Zhang, Cao, et al. "Chemical structures of polyphenols that critically influence the toxicity of ZnO nanoparticles." Journal of agricultural and food chemistry 66.7 (2018): 1714-1722.https://doi.org/10.1021/acs.jafc.8b00368 4. [IF=5.279] Cao Zhang et al."Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles."J Agr Food Chem. 2018;66(7):1714–1722 5. [IF=6.922] Kangfeng Jiang et al."Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis."J Inflamm Res. 2021; 14: 2963–2978 6. [IF=5.396] Alex GAO et al."Luteolin Stimulates the NGF-induced Neurite Outgrowth in Cultured PC12 Cells through Binding with NGF and Potentiating its Receptor Signaling."Food Funct. 2021 Oct;: 7. [IF=5.279] Qiang You et al."Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma."J Agr Food Chem. 2021;69(43):12705–12716 8. [IF=3.978] Yunbin Lyu et al."Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai."Biochem Eng J. 2020 Nov;163:107759 9. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788 10. [IF=3.263] QingLing Jia et al."Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells."Eur J Pharmacol. 2019 Dec;865:172748 11. [IF=1.785] Li Yan et al."Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX‑1 in apoE‑/‑ mice."Exp Ther Med. 2021 Jan;21(1):1-1 12. [IF=1.554] Ping Tang et al."Electrochemical antioxidant screening and evaluation based on guanine and chitosan immobilized MoS2 nanosheet modified glassy carbon electrode (guanine/CS/MoS2/GCE)."Open Chem. 2020 Jan;18(1):1-9 13. [IF=6.514] Yan Guo et al."Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli."Eur J Med Chem. 2022 Jan;:114108 |
528-48-3 - Reference Information
| color index | 75620 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | luffin (Fisetin) is a polymer pharmaceutical raw material. This product is a yellow needle-like crystal, derived from the lacquer family plants, wax tree RhussuccedaneaL, coggygria, etc. Soluble in ethanol, acetone and acetic acid. Almost insoluble in water, ether, benzene, chloroform and petroleum ether. It has an inhibitory effect on the production of prostate cord in 3T3 mice fibroblasts with methylcholanthracene transmutation, and the half effective inhibitory concentration (ID50) is 42.0UM. It has inhibitory effect on the whole sugar reductase of rat eye lens, and the half effective inhibitory concentration is 10-6M; for mouse small intestine specimens, its anti-acetylcholine spasmodic effect is the 166% of papaverine. A team of Japanese and American researchers found through animal experiments that the lutein in vegetables and fruits can help improve memory. |
| detection method | HPLC ≥ 98% |
| specifications | 10 mg20mg100mg500mg1g (can be packaged according to customer requirements) |
| traits | this product is yellow needle crystal |
| function and use | this product is used for content determination. |
| extraction source | this product is extract of sumac plant fig. 1 one of the sources of envery flavin-coggygria extract |
| physical properties | yellow needle crystal (dilute ethanol), melting point 330 ℃ (decomposition). Soluble in ethanol, acetone and acetic acid. Almost insoluble in water, ether, benzene, chloroform and petroleum ether. Melting point 348 ℃, bright yellow fine needle crystal , melting point> 300 ℃ |
| pharmacological action | 1. inhibition of prostaglandin: inhibitory effect on the formation of prostatic cord in 3T3 mouse fibroblasts transformed from methylcholanthracene, with a half effective inhibitory concentration (ID50) of 42.0UM. 2. Enzyme inhibition: it has inhibitory effect on the whole sugar reductase of rat eye lens, and the half effective inhibitory concentration is 10-6M 3. antispasmodic: on mouse small intestine specimens, its antiacetylcholine spasmodic effect is the 166% of papaverine. 4. A team composed of Japanese and American researchers found through animal experiments that the lutein in vegetables and fruits can help improve memory. |
| extraction rate experiment | 20g of yellow protection was weighed, totaling 5 batches. Under the optimal extraction process, reflux extraction until the extract is nearly colorless, combine the extract, filter and concentrate, move to a 1000ml volumetric flask, add ethanol to the scale, and shake well. accurately absorb 1ml and place it in a 100ml volumetric flask, add ethanol to dilute to scale, shake well, measure its absorbance at 367±1nm wavelength of ultraviolet spectrophotometer according to the determination method of envery flavin content in yellow pond pulp, calculate the content and extraction rate of envery flavin in the sample according to the 847.52 of C12H10O6 absorption coefficient, and see table 1 for the results. table 1 extraction rate of luffin in coggygria coggygria |
| references | [1] lutein. Bailian database.[2017/08.20] [2] Fisetin.[2017/08.20] [3] Tang Jianhua, Shen Qingliang. Study on extraction rate of luffin from Cotinus coggygria [J]. Chinese patent medicine, 1992,(08):10. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: 1. Inhibition of prostaglandins: It has an inhibitory effect on the formation of the prostate cord of 3T3 mice fibroblasts mutated by methylcholanthracene, and the half effective inhibitory concentration (ID50) is 42.0UM. 2. Enzyme inhibition: It has inhibitory effect on the whole sugar reductase of rat eye lens, and the half effective inhibitory concentration is 10-6M. 3. Antispasmodic: For small intestine specimens of mice, its antispasmodic effect against acetylcholine is the 166% of papaverine. 4. A team of Japanese and American researchers found through animal experiments that the lutein in vegetables and fruits can help improve memory. a naturally occurring flavonol with therapeutic activity, used to synthesize anti-inflammatory, anticonvulsant and antiproliferative drugs with pharmaceutical activity. |
Last Update：2024-04-09 20:49:11
Supplier List
Featured ProductsSpot supply
Product Name: Fisetin Visit Supplier Webpage Request for quotationCAS: 528-48-3
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
Spot supply
Product Name: Fisetin Request for quotationCAS: 528-48-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Fisetin Request for quotation
CAS: 528-48-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 528-48-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: Fisetin Visit Supplier Webpage Request for quotationCAS: 528-48-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Fisetin Request for quotation
CAS: 528-48-3
Tel: 0755-27208059
Email: alex@hygieia.com.cn
Mobile: 13342904611
QQ: 3445655213
Send QQ message
CAS: 528-48-3
Tel: 0755-27208059
Email: alex@hygieia.com.cn
Mobile: 13342904611
QQ: 3445655213
Featured ProductsSpot supply
Product Name: Fisetin Visit Supplier Webpage Request for quotationCAS: 528-48-3
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
Spot supply
Product Name: Fisetin Request for quotationCAS: 528-48-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Fisetin Request for quotation
CAS: 528-48-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 528-48-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: Fisetin Visit Supplier Webpage Request for quotationCAS: 528-48-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Fisetin Request for quotation
CAS: 528-48-3
Tel: 0755-27208059
Email: alex@hygieia.com.cn
Mobile: 13342904611
QQ: 3445655213Send QQ message
CAS: 528-48-3
Tel: 0755-27208059
Email: alex@hygieia.com.cn
Mobile: 13342904611
QQ: 3445655213
View History