52805-46-6

52805-46-6 - Names and Identifiers

Name	3-HYDROXY-4-METHOXYBENZONITRILE
Synonyms	ISOVANILLONITRILE 2-Methoxy-5-cyanophenol 5-Cyano-2-methoxyphenol 3-Hydroxy-4-methoxybenzonitril 3-HYDROXY-4-METHOXYBENZONITRILE Benzonitrile, 3-hydroxy-4-Methoxy- 3-HYDROXY-4-METHOXYBENZONITRILE (ISOVANILLONITRILE) Gefitinib IMpurity (3-Hydroxy-4-Methoxybenzonitrile)
CAS	52805-46-6
InChI	InChI=1/C8H7NO2/c1-11-8-3-2-6(5-9)4-7(8)10/h2-4,10H,1H3

52805-46-6 - Physico-chemical Properties

Molecular Formula	C8H7NO2
Molar Mass	149.15
Density	1.24±0.1 g/cm3(Predicted)
Melting Point	124 °C
Boling Point	300.8±27.0 °C(Predicted)
Flash Point	135.7°C
Vapor Presure	0.000613mmHg at 25°C
Appearance	Bright light brown crystalline powder
pKa	8.59±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.568
MDL	MFCD02258854

52805-46-6 - Risk and Safety

HS Code

29269090

52805-46-6 - Introduction

It is an organic compound with the formula C8H7NO2. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White crystal or crystalline powder.
-Melting point: about 110-112 degrees Celsius.
-Solubility: Soluble in many organic solvents, such as alcohols, esters and ethers, insoluble in water.

Use:
-is an important organic synthesis intermediate, which is often used as a starting material in drug synthesis. It can be used as a synthetic raw material for anti-inflammatory drugs and cholinesterase inhibitors.

Preparation Method:
-or can be prepared by the oxidation of hydroxybenzonitrile by parafrin. First, p-meflurane is reacted with an oxidizing agent, such as hydrogen peroxide, to form p-methoxybenzonitrile. The p-methoxybenzonitrile is then subjected to boric acid catalyzed hydrogenation to reduce the methoxy group to a hydroxyl group.

Safety Information:
-Toxicity information is limited. However, like other chemicals, it should follow appropriate safe handling procedures in a laboratory environment, such as wearing personal protective equipment (gloves, glasses, laboratory coats, etc.), and storing in a dry, well-ventilated place. For detailed safety information, reference should be made to the relevant safety data sheet for the compound.

Last Update：2024-04-09 21:01:54