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53-03-2

prednisone

CAS: 53-03-2

Molecular Formula: C21H26O5

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53-03-2 - Names and Identifiers

Name prednisone
Synonyms Cortan
Colisone
Bicortone
Ancortone
prednisone
Prednisone
1,2-Dehydrocortisone
11,20-trione,17,21-hydroxy-pregna-4-diene-3
11,20-trione,17,21-dihydroxy-pregna-4-diene-3
1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione
17-alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
CAS 53-03-2
EINECS 200-160-3
InChI InChI=1/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14?,15?,18?,19-,20-,21-/m0/s1

53-03-2 - Physico-chemical Properties

Molecular FormulaC21H26O5
Molar Mass358.43
Density1.1121 (rough estimate)
Melting Point236-238°C(lit.)
Boling Point410.86°C (rough estimate)
Specific Rotation(α)169 º (c=0.5, dioxane)
Flash Point>200℃
Water Solubility115mg/L(25 ºC)
Solubility Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
Vapor Presure1.51E-15mmHg at 25°C
AppearanceSolid
ColorWhite to Off-White
Merck7722
BRN2065301
pKa12.36±0.60(Predicted)
Storage Condition2-8°C
StabilityStable. Incompatible with strong oxidizing agents.
Refractive Index170 ° (C=0.5, Dioxan
Physical and Chemical PropertiesWhite or off-white crystalline powder, no odor, slightly bitter taste. Practically insoluble in water, slightly soluble in ethanol (1:190) and chloroform (1:200). Mp233-235 C (decomposition), than the optical rotation [alpha] 25D 172 degrees (dioxane), the product of acetic acid solution at 240nm wavelength has the maximum absorption.
UseCommonly used in combination chemotherapy, can improve the general condition of patients, can also be used for acute leukemia and other tumors

53-03-2 - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR63 - Possible risk of harm to the unborn child
Safety DescriptionS36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S16 - Keep away from sources of ignition.

53-03-2 - Standard

Authoritative Data Verified Data

This product is 17a ,21-dihydroxyprogestin -1, 4-diene-3, 11, 20-trione. The content of C21H2605 shall be 97.0% ~ 102.0% calculated as dry product.

Last Update：2024-01-02 23:10:35

53-03-2 - Trait

Authoritative Data Verified Data
  • This product is white or white crystalline powder; Odorless.
  • This product is slightly soluble in ethanol or chloroform, and is almost insoluble in water.

specific rotation

take this product, precision weighing, plus dioxane dissolution and quantitative dilution of about 5mg per lml solution, according to the law (General 0621), the specific rotation was 167 ° to 175 °.

absorption coefficient

take this product, precision weighing, plus ethanol dissolution and quantitative dilution to make a solution containing about 15ug per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 240nm, and the absorption coefficient was 405 to 435.

Last Update：2022-01-01 13:38:07

53-03-2 - Differential diagnosis

Authoritative Data Verified Data
  1. take about 5mg of this product, add 2ml sulfuric acid to dissolve it, and place it for 5 minutes to show orange color; Pour this solution into 10ml water, and the solution will turn yellow and gradually turn blue-green.
  2. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  3. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 612).
Last Update：2022-01-01 13:38:08

53-03-2 - Exam

Authoritative Data Verified Data

Related substances

take this product, precision weighing, adding mobile phase to dissolve and quantitatively dilute to make a solution containing about 0.5mg per lml as a test solution; Take 1ml for precision measurement, in a 100ml measuring flask, dilute to the scale with the mobile phase, shake well, and use as a control solution; Take the cortisone control, dissolve and quantitatively dilute with the mobile phase to make a solution containing about 5ug per 1ml, as a control solution. According to the chromatographic conditions under the content determination item, 20ul of each of the test solution, the control solution and the reference solution are accurately measured and injected into the human liquid chromatograph respectively, the chromatogram was recorded to 2.5 times of the retention time of the main component peak. If there are peaks in the chromatogram of the test solution that are consistent with the retention time of the pine peak in the chromatogram of the reference solution, the peak area shall be calculated according to the external standard method, and shall not exceed 0.5%; other single impurity peak area shall not be greater than 0.5 times (0.5%) of the main peak area of the control solution, and the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.01 times smaller than the main peak area of the control solution were ignored.

loss on drying

take about 0.5g of this product, dry at 105°C for 3 hours, and lose no more than 1.0% of weight (General rule 0831).

Last Update：2022-01-01 13:38:09

53-03-2 - Content determination

Authoritative Data Verified Data
  • measured by high performance liquid chromatography (General 0512).
  • chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Acetonitrile-water (24:76) as mobile phase; Detection wavelength of 240mn. Prednisone and cortisone were taken, dissolved and diluted with mobile phase to make a solution containing about 5ug of each lml. 20ul was injected into human liquid chromatograph and the chromatogram was recorded, the degree of separation between prednisone peak and cortisone peak should be greater than 3.4.
  • determination of this product, precision weighing, plus mobile phase dissolution and quantitative dilution of about 50% per 1 mL solution, as a test solution, A 20ul injection liquid chromatograph was used to record the chromatogram. Another prednisone reference substance was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 13:38:09

53-03-2 - Category

Authoritative Data Verified Data

adrenocortical hormone drugs.

Last Update：2022-01-01 13:38:09

53-03-2 - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 13:38:10
53-03-2
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Prednisone Request for quotation
CAS: 53-03-2
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CAS: 53-03-2
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Prednisone Request for quotation
CAS: 53-03-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: prednisone Request for quotation
CAS: 53-03-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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53-03-2
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