53-21-4
COCAINE HYDROCHLORIDE
CAS: 53-21-4
Molecular Formula: C17H22ClNO4
53-21-4 - Names and Identifiers
53-21-4 - Physico-chemical Properties
| Molecular Formula | C17H22ClNO4 |
| Molar Mass | 339.81 |
| Melting Point | 200-2020C |
| Specific Rotation(α) | D -72° (c = 2 in aq soln pH 4.5) |
| Solubility | Very soluble in water, freely soluble in alcohol, slightly soluble in methylene chloride. |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Colorless, odorless monoclinic crystals. Melting point 98 ℃. Almost insoluble in water, soluble in general organic solvents. The taste is bitter first and then hemp. Its hydrochloride, C17H21NO4 · HCI, colorless crystal or white crystalline powder, melting point above 197 ℃. Easily soluble in water, easily soluble in ethanol, soluble in chloroform, insoluble in ether. |
53-21-4 - Risk and Safety
| Risk Codes | R60 - May impair fertility R25 - Toxic if swallowed R43 - May cause sensitization by skin contact R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S22 - Do not breathe dust. S53 - Avoid exposure - obtain special instructions before use. |
| UN IDs | UN 1544 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | YM3050000 |
| HS Code | 2939710000 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
53-21-4 - References
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | cocaine is soluble in ethanol, chloroform, ether, benzene, petroleum ether, etc., slightly soluble in water. Dissolved in dilute hydrochloric acid and three chromium chloride solution to generate orange yellow precipitation, and potassium permanganate solution to generate purple crystalline precipitation. The total alkaloids were extracted from the leaves of coca with ethanol, and were obtained by hydrolysis, benzoylation, methyl esterification, etc. A local anesthetic that blocks the conduction of nerve fibers and is used as its hydrochloride. |
| Use | has a local anesthetic effect, and its 0.03 aqueous solution can anesthetize sensory nerve endings. The aqueous solution of cocaine and its hydrochloride is decomposed when boiling Disinfection, which is inconvenient to use and is now replaced by other synthetic local anesthetics. Currently, it is still commonly used as a mucosal anesthetic in ophthalmology. Cocaine on the central nervous system has a greater toxicity, can make the cerebral cortex excited euphoric, repeated use, can quickly produce addiction, become a drug. |
| production method | cocaine is a tropane-type alkaloid that can be extracted from the leaves of the plant coca. The coca leaf powder was extracted with ethanol, the extract was recovered from ethanol, concentrated under reduced pressure, and the concentrated solution was extracted with chloroform to obtain total alkaloids. Cocaine is an ester, which is hydrolyzed with acid or alkali to generate benzoic acid, methanol and L-aikangning. This reaction can be carried out in the reverse direction to esterify and acylate aikangning, all the derivatives of Icotinib can be converted into cocaine. The cocaine and acetone were heated to 40 °c, dissolved, activated carbon was added, and stirred for 10min. Filtration, neutralization of the filtrate with an ethanolic solution of hydrogen chloride, freezing of the crystals, filtration, washing of the crystals with acetone, and drying below 70 ° C. Yielded the cocaine hydrochloride. |
Last Update：2024-04-09 21:04:16
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Product Name: *Cocaine Monomer Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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