53360-85-3

53360-85-3 - Names and Identifiers

Name	2-Amino-1-(4-methylphenyl)ethanol
Synonyms	AKOS BBV-002874 2-AMINO-1-P-TOLYL-ETHANOL 2-Amino-1-(4-methylphenyl)ethanol 2-amino-1-(4-methylphenyl)ethanol 2-AMino-1-(4-Methylphenyl)ethanol HCl α-(AMinoMethyl)-4-Methylbenzyl Alcohol α-(AMinoMethyl)-p-Methylbenzyl Alcohol α-(AMinoMethyl)-4-Methyl-benzeneMethanol Benzenemethanol, a-(aminomethyl)-4-methyl- BENZENEMETHANOL, α-(AMINOMETHYL)-4-METHYL-
CAS	53360-85-3

53360-85-3 - Physico-chemical Properties

Molecular Formula	C9H13NO
Molar Mass	151.21
Density	1.076±0.06 g/cm3(Predicted)
Melting Point	68-69 °C(Solv: hexane (110-54-3))
Boling Point	300.9±27.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White
pKa	12.17±0.35(Predicted)
Storage Condition	-20°C Freezer

53360-85-3 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

53360-85-3 - Introduction

2-Amino-1-(4-methylphenyl)ethanol is an organic compound with the chemical formula C9H13NO. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White solid
-Melting point: 63-65 degrees Celsius
-Melting: Soluble in water and organic solvents
- pH: Neutral (about 7)
-Molecular weight: 155.21g/mol

Use:
2-Amino-1-(4-methylphenyl)ethanol has certain application value in the field of medicine and chemical industry:
1. In drug synthesis, it is often used as an intermediate for the synthesis of verapamil calcium channel blockers.
2. The compound has certain biological activity, so it can also be used as a reference compound in drug screening.

Preparation Method:
The preparation method of 2-Amino-1-(4-methylphenyl)ethanol is more complicated. A common method is to synthesize it through the following steps:
1.4-methyl ether is reacted with sodium hydroxide to generate 4-methyl phenol.
2.4-methyl phenol is reacted with methyl magnesium bromide to generate 4-methyl benzyl alcohol.
3. react 4-methyl benzyl alcohol with aminoethanol to generate the final product 2-Amino-1-(4-methylphenyl)ethanol.

Safety Information:
2-Amino-1-(4-methylphenyl)ethanol should follow the following safety procedures:
-Inhalation, ingestion or contact with skin and eyes may cause irritation and discomfort. Avoid direct contact.
-Good ventilation measures should be taken during handling.
-Use personal protective equipment such as gloves, goggles and protective clothing.
-Avoid contact with oxidants and combustibles.
-Store in a dry, cool, well-ventilated place away from sources of fire.

Last Update：2024-04-09 02:00:46