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537-42-8

trans-Pterostilbene

CAS: 537-42-8;18259-15-9

Molecular Formula: C16H16O3

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537-42-8 - Names and Identifiers

Name trans-Pterostilbene
Synonyms AKOS 236-80
PTEROSTILBENE
pterostilbene
trans-Pterostilbene
pterocarpus marsupium
PTEROCARPUS MARSUPIUM
3',5'-DIMETHOXY-4-STILBENOL
3',5'-Dimethoxy-4-stilbenol
3,5-dimethoxy-4'-hydroxystilbene
3,5-DIMETHOXY-4'-HYDROXYSTILBENE
trans-3',5'-Dimethoxy-4-stilbenol
4-Stilbenol, 3',5'-dimethoxy-, (E)-
(E)-3,5-Dimethoxy-4'-hydroxystilbene
Trans-3,5-dimethoxy-4'-hydroxystilbene
TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE
3,5-Dimethoxy-4'-hydroxy-trans-stilbene
4-(E)-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol
4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL
Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-
CAS 537-42-8
18259-15-9
EINECS 611-041-4
InChI InChI=1/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

537-42-8 - Physico-chemical Properties

Molecular FormulaC16H16O3
Molar Mass256.3
Density1.169±0.06 g/cm3(Predicted)
Melting Point89-92 ºC
Boling Point420.4±35.0 °C(Predicted)
Flash Point208.1°C
Solubility Soluble in hot methanol and DMSO, insoluble in water.
Vapor Presure1.15E-07mmHg at 25°C
AppearanceWhite crystal
ColorWhite or off-white
Maximum wavelength(λmax)['321nm(MeOH)(lit.)']
pKa9.96±0.26(Predicted)
Storage Condition2-8°C
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
SensitiveSensitive to light and air
Refractive Index1.639
MDLMFCD00238710
Physical and Chemical PropertiesSoluble in hot methanol, DMSO, insoluble in water. From the leguminous plant pterostilbene pterostilbene (Pterocarpus indicus)

537-42-8 - Risk and Safety

Risk CodesR41 - Risk of serious damage to eyes
R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. 
UN IDs3077
WGK Germany3
HS Code29095000
Hazard ClassIRRITANT
Packing GroupⅢ

537-42-8 - Reference

Reference
Show more
1. Liu, Pengpeng, Guoxian, Zhang Fan et al. UPLC-MS comparison of contents of 12 active components in astragalus membranaceus prepared by directional processing with organic acid [J]. Chinese Journal of Traditional Chinese Medicine, 2020 v.45(01):121-126.
2. Zhong Gui-lan, well-known, Wang Ru, et al. Effects of pterostilbene on autophagy and SIRT1-FoxO signaling pathway in cervical cancer cells [J]. Chinese Journal of pathophysiology, Volume 36, 20208, pages 1439-1443, ISTIC PKU CSCD CA, 2020.
3. Chen Hong. Synergistic Effect of pterostilbene and acetylshikonin on proliferation of B16F10 cells [J]. Chinese pharmacological Bulletin, 32(06):818-824.
4. Zhong Guilan, as we all know, Wang Ru, Fu Shanhua, Liu Xiaofang. Effects of pterostilbene on autophagy and SIRT1-FoxO signaling pathway in cervical cancer cells [J]. Chinese Journal of pathophysiology, 2020,36(08):1439-1443.
5. [IF = 3.998] Chenhao Tong et al."pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway." Sci Rep-Uk. 2021 Feb;11(1):1-10

537-42-8 - Reference Information

Overview Pterostilbene is a chemical component contained in Pterosalwood, but scientists have also discovered the existence of Pterostilbene in other plants. However, it was named Pterostilbene for the first time because of its discovery and Pterostilbene species. Pterostilbene is a white or white-like powder crystal, which has rich medicinal value. It is an antifungal active ingredient in draconis products. It has certain effects on the treatment of cancer, hypertension and hyperlipidemia. Recently, researchers have mastered the industrial synthesis method of red sandalwood.
pterostilbene is an antifungal active ingredient in draconis products. It is a polyhydroxystilbene compound and is a homolog of resveratrol. Its pharmacological effects are partially similar to resveratrol. Besides, it also has strong antifungal activity (its antifungal activity is five times that of resveratrol).
character description white crystalline powder, sensitive to air
safety after accidental contact with eyes, please rinse with plenty of water and consult a doctor immediately. Wear goggles or masks. Avoid release into the environment. Refer to the special instructions/safety data specification.
risk serious eye damage. It is toxic to aquatic organisms and may have long-term adverse effects on the water environment.
dangerous goods mark irritating articles
articles harmful to the environment
hazard description hazard code: Xi,N
hazard level: 41-51/53
safety level: 26-39-61
united nations code: UN3077
uses antioxidant, anti-cell proliferation, hypolipidemic, inhibition of COX-1 and COX-2, anti-cancer, anti-fungal
antioxidant, anti-inflammatory, anti-thrombotic, anti-cancer, anti-hyperlipidemia, antibacterial and other activities
antioxidant, anti-cell proliferation, hypolipidemic, inhibition of COX-1 and COX-2, anti-cancer, anti-fungal
pterostilbene and disease pterostilbene helps prevent pre-cancer damage to the body. As an antioxidant and anti-inflammatory agent, it is found in blueberries and blackberries. The University of Ohio found that animals eating rough berries had a 80% lower risk of colon cancer and a 60% lower risk of digestive tract tumors.
colon cancer is one of the common malignant tumors, with the highest incidence in the 40-50 age group. According to the world epidemiological survey, it is found that colon cancer has the highest incidence in North America, Western Europe, Australia, New Zealand and other places, ranking second in visceral tumors. The incidence and mortality in my country are increasing year by year.
After many years of experiments on animals, American scientists have discovered that extracting this compound from blueberries and grapes can inhibit an enzyme called "P450 cytochrome", which can activate chemical carcinogens and reduce low-density lipoprotein cholesterol. Therefore, it has the function of preventing cancer and heart disease. Pterostilbene is a aromatic hydrocarbon called "styrene", which is a derivative of resveratrol. In the early 1990s, American scientists discovered that resveratrol has the function of preventing breast cancer and heart disease, and it exists in a large number of red grape skins.
artificial synthesis method using 3, 5-dimethoxybenzyl bromide and p-nitrobenzaldehyde as raw materials, the target was obtained by Witting-Hornor reaction, reduction, diazotization and hydrolysis. the natural multifunctional antioxidant pterosperm was synthesized with a total yield of 53.9%, and the structure of the target was characterized by IR, 1HNMR and EI-MS. The synthesis process is simple, easy to operate, low production cost, and has a good industrial application prospect.

figure 1 artificial synthesis path of pterostilbene
References [1] Rosewood stilb. Bailian Database. [Citation Date 2017.09.07]
[2] Xu Fangfang, Qi Rui, Jiang Shiwei, Guo Dean, Liu Bo. Research Progress of Pterossylum [J/OL]. New Drugs and Clinical Pharmacology of Traditional Chinese Medicine, 2017,28(03):406-410. (2017-04-01)
[3] Zhang erting. red sandalwood and its application in dermatology [a]. China association of integrated traditional Chinese and western medicine dermatology professional Committee. Compilation of Papers from 2015 National Annual Conference on Dermatology and Venereology of Integrated Traditional Chinese and Western Medicine [C]. Professional Committee of Dermatology and Venereology of Chinese Society of Integrated Traditional Chinese and Western Medicine:,2015:1.
Last Update：2024-04-09 21:51:49
537-42-8
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 537-42-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Zouping Mingxing Chemical Co., Ltd.
Product Name: Pterostilbene  Request for quotation
CAS: 537-42-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Pterostilbene Request for quotation
CAS: 537-42-8
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
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HN Langyue Biotech Co.,Ltd
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CAS: 537-42-8
Tel: 0731-86393263
Email: 371788615@qq.com
Mobile: 18975106251
Wuhan Shuer Biological Technology Co., Ltd.
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CAS: 537-42-8
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Mobile: 13277972784
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