53846-50-7
8-Prenylnaringenin
CAS: 53846-50-7
Molecular Formula: C20H20O5
53846-50-7 - Names and Identifiers
53846-50-7 - Physico-chemical Properties
| Molecular Formula | C20H20O5 |
| Molar Mass | 340.37 |
| Density | 1.314±0.06 g/cm3(Predicted) |
| Melting Point | 202-204 195.5-196℃ |
| Boling Point | 597.6±50.0 °C(Predicted) |
| Specific Rotation(α) | ?25 (c, 0.1 in EtOH) |
| Solubility | Methanol; Ether |
| Appearance | neat |
| BRN | 5611472 |
| pKa | 7.70±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from hops Humulus lupulus. |
| Use | Cytotoxic |
53846-50-7 - Risk and Safety
| WGK Germany | 3 |
53846-50-7 - Reference Information
| Overview | 8-Prenylnaringenin (8PN) it is a kind of isoamyl flavone with estrogenic effect found in hops. It is reported in the literature that 8PN is the most potential plant female hormone discovered so far. In vivo and in vitro studies have shown that 8PN has a strong estrogenic effect, which can play a role in low doses. Compared with the discovered soy isoflavones, genistein and other phytoestrogens, the effect is stronger, it can effectively alleviate various symptoms of menopause in women, and has weak side effects, and is considered to be a new type of plant female Hormone instead of Hormone Replacement Therapy (HRT). |
| function | 8-isopentenyl naringenin also has the effects of preventing cancer, preventing osteoporosis, inhibiting vascular proliferation, antioxidant and other effects. |
| preparation | a method for synthesizing 8-isopentenyl naringenin by microbial cells catalyzed by isoxanthohumol, comprising: (1) to the culture solution, insert Penicillium javanicum CGMCC NO.3.5706 to obtain the pre-reaction system; (2) to step (1) the obtained pre-reaction system is added with an isoxanthohumol solution at 25-30 °c, preferably 28 °c, and the conversion reaction is carried out for 5-7 days, preferably 6 days, to obtain a converted culture solution, the dosage of isoxanthohumol is 0.01-0.1g, preferably 0.02g, per liter of culture solution; (3) the transformed culture solution is post-treated to obtain 8-isopentenylnaringenin. |
| biological activity | 8-prenylnaringenin is an isopentene flavonoid isolated from hops, cytotoxic. 8-precylnaringenin can induce apoptosis mediated by endogenous and exogenous pathways, and produce anti-proliferative activity on HCT-116 colon cancer cells. 8-precylnaringenin promotes recovery from quiescent-induced discontinuation muscle atrophy by activating the mouse Akt phosphorylation pathway. |
Last Update：2024-04-09 20:48:19
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Product Name: 8-Prenylnaringenin Visit Supplier Webpage Request for quotationCAS: 53846-50-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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