543-20-4
Succinyl chloride
CAS: 543-20-4
Molecular Formula: C4H4Cl2O2
543-20-4 - Names and Identifiers
| Name | Succinyl chloride |
| Synonyms | succinicchloride Succinic chloride Succinyl chloride succinoylchloride Succinoyl chloride Succinyl dichloride Succinoyl dichloride BUTANEDIOYL CHLORIDE Butanedioyldichloride Butanedioyl dichloride Succinic acid dichloride 1,2-Bis(Chlorocarbonyl)ethane 1,2-ethanediylbis(chloroformate) |
| CAS | 543-20-4 |
| EINECS | 208-838-0 |
| InChI | InChI=1/C4H4Cl2O2/c5-3(7)1-2-4(6)8/h1-2H2 |
543-20-4 - Physico-chemical Properties
| Molecular Formula | C4H4Cl2O2 |
| Molar Mass | 154.98 |
| Density | 1.407g/mLat 25°C(lit.) |
| Melting Point | 16 °C |
| Boling Point | 190°C(lit.) |
| Flash Point | 170°F |
| Water Solubility | Reacts violently with water. |
| Vapor Presure | 0.466mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to slightly brown |
| Merck | 14,8873 |
| BRN | 507064 |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.468(lit.) |
| Physical and Chemical Properties | Colorless liquid or leaf-like crystals. Melting point 20 °c (17 °c). Boiling point 192-193 °c, 103-104 °c (3.33kPa). Relative density 1.3948(15/4 C). Refractive index 1.473(15 degrees C). Flash point 76 °c. Soluble in ether and benzene, insoluble in petroleum ether, water and alcohol decomposition. Corrosive, smoking. |
| Use | Skeletal muscle relaxant, used as an adjunct to general anesthesia |
543-20-4 - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R14 - Reacts violently with water R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| RTECS | WN4900000 |
| TSCA | Yes |
| HS Code | 2917 19 80 |
| Hazard Class | 8 |
| Packing Group | II |
543-20-4 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | this product is an intermediate of synthetic resin, coating and drug succinylcholine chloride. Skeletal muscle relaxant, used as an auxiliary drug for general anesthesia Analytical titration water. Organic synthesis. |
| Production method | It is obtained by the reaction of succinic acid and phosphorus pentachloride. Add succinic acid, phosphorus pentachloride and anhydrous chloroform to the reaction pot in turn. When the intense reaction slows down, heat to reflux. When the reactants are all turned into liquid, evaporate the low boiling substance to recover chloroform, and then distill under reduced pressure to recover phosphorus oxychloride. The residual liquid is further heated, and the distillation is continued under reduced pressure to collect the fraction of 95-110 ℃(2.67kPa), which is succinyl chloride. The yield is about 88%. |
| category | corroded articles |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-mouse LDL0: 62.5 mg/kg |
| flammability hazard characteristics | combustible; decomposes toxic chloride gas in contact with water; combustion produces toxic chloride smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidant and alkali. |
| fire extinguishing agent | dry sand, dry stone powder, carbon dioxide; No water |
Last Update：2024-04-09 15:16:51
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