Name | 3-BROMO-5-NITROBENZAMIDE |
Synonyms | 3-BROMO-5-NITROBENZAMIDE Benzamide, 3-bromo-5-nitro- |
CAS | 54321-80-1 |
Molecular Formula | C7H5BrN2O3 |
Molar Mass | 245.03 |
Storage Condition | Sealed in dry,Room Temperature |
Hazard Symbols | Xi - Irritant |
Hazard Note | Irritant |
Application | 3-bromo-5-nitrobenzamide, a poly (ADP-ribose) polymerase inhibitor, as an anti-tumor agent, it is currently in the clinical research stage. |
preparation | add 3.7g 3-bromo-5-nitrobenzoic acid methyl ester and 30ml methanol into the reaction flask, stir at 35 °c, ammonia, TLC monitoring reaction process, the development of solvent volume ratio of ethyl acetate: petroleum ether = 1:1. After completion of the reaction, the reaction solution was evaporated to dryness to give 3.3g of a crude yellow solid. The crude product was recrystallized from 3.0 ml of ethanol, and filtered with suction to obtain yellow crystals, which were dried under vacuum to obtain 99.75G 3-bromo-5-nitrobenzamide. The HPLC purity was 85.2 and the yield was ﹪. |