546-97-4
Columbin
CAS: 546-97-4
Molecular Formula: C20H22O6
546-97-4 - Names and Identifiers
546-97-4 - Physico-chemical Properties
| Molecular Formula | C20H22O6 |
| Molar Mass | 358.39 |
| Density | 1.36 |
| Melting Point | 190-191℃ |
| Boling Point | 410.82°C (rough estimate) |
| Specific Rotation(α) | D +52.5° (pyridine) |
| Solubility | Easily soluble in methanol and ethyl acetate, almost insoluble in water |
| Appearance | White crystal |
| pKa | 12.14±0.70(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.4450 (estimate) |
| MDL | MFCD02682955 |
| Physical and Chemical Properties | White needle-like crystal, easily soluble in methanol, ethyl acetate, almost insoluble in water, derived from Jin Guolan. |
| In vitro study | Treatment with columbin or l-NAME inhibits LPS/IFN-γ-induced NO production without affecting the viability of RAW264.7. Pre-treatment of stimulated cells with columbin does not inhibit the translocation of NF-κB to the nucleus in LPS-stimulated cells. COX-1 and COX-2 inhibitory activities of columbin are 63.7±6.4% and 18.8±1.5% inhibition at 100μM, respectively. The interaction of columbin with Tyr385 and Arg120 signifies its higher activity in COX-2, as Tyr385 is reported to be involved in the abstraction of hydrogen from C-13 of arachidonate, and Arg120 is critical for high affinity arachidonate binding. |
| In vivo study | Columbin inhibits oedema formation in mice paw. At doses of 300 mg/kg and 700 mg/kg, columbin inhibits inflammation from 0 to 5 h and the results are comparable to that of aspirin as a standard anti-inflammatory drug. The inhibitory effect of columbin on carrageenan induced paw oedema in mice may be due to the suppression of the release of mediators responsible for inflammation including prostaglandin. Columbin is poorly bioavailable (2.8% p.o. and 14% i.p.) in rats, but its transport is rapid across the Caco-2 cell monolayers, suggesting that extensive first-pass metabolism in the liver is the likely reason for its poor bioavailability. |
546-97-4 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29322090 |
546-97-4 - Reference
| Reference Show more | 1. Lin Caizhi, Xie Haiyuan, Huang Zhenqing, etc. Effects of the active ingredients of zhuangyao Xinji Grubin and African Tetrandrine on the promoter of HBV [J]. Pharmacology and Clinic of traditional Chinese medicine, 2019, 035(004):72-77. |
546-97-4 - Introduction
Columbin is a glial substance made from animal bones, ligaments, and skin. It is a colorless and odorless semi transparent gel, mainly composed of protein and water.
Columbin has multiple uses. It is commonly used in the food industry as a coagulant, stabilizer, and thickener. Columbin can be used to make foods such as jelly, candy, pudding, cheese, frozen products, etc., providing the necessary solidification and taste for these foods. In addition, Columbin can also be used to make capsule drug shells, capsule photographic films, medical dressings, and blood products.
In terms of preparation method, the preparation process of Columbin usually includes the following main steps: first, wash and treat the animal bones, ligaments, and skin to remove impurities. Then, soak the purified animal tissue in water for protein dissolution. Subsequently, the protein solution is purified and concentrated into a gel like substance through processes such as steaming, filtration, and concentration. Finally, after drying and crushing, the finished product can be obtained.
Columbin is generally safe because it is mainly composed of natural proteins. However, individuals may be allergic to Columbin, causing allergic reactions such as rash, difficulty breathing, etc. People with a history of allergies or allergies to animal proteins should be cautious when using Columbin products. In addition, it should be noted that some Columbin products may contain other additives or impurities that may cause allergies, so extra caution should be taken when selecting and using them.
Last Update：2024-04-09 21:46:18
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Product Name: Columbin Visit Supplier Webpage Request for quotation
CAS: 546-97-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 546-97-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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