548-76-5

548-76-5 - Names and Identifiers

Name	5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4-benzopyrone
Synonyms	Rrigenin 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4-benzopyrone 5,7-Dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-
CAS	548-76-5
EINECS	208-958-3

548-76-5 - Physico-chemical Properties

Molecular Formula	C18H16O8
Molar Mass	360.31
Density	1.461±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	189-192℃
Boling Point	646.1±55.0 °C(Predicted)
Solubility	Soluble in methanol, ethanol, DMSO and other organic solvents
Appearance	White crystalline powder
pKa	6.36±0.20(Predicted)
Storage Condition	2-8°C
MDL	MFCD00597047
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from shegan.
In vitro study	Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition.

548-76-5 - Reference

Reference

1. Yang Yawen, Liu Yong, Liu Yu, Du Hongzhi, Liu assembly, Huang Bicheng. Effects of different drying methods on drying characteristics, appearance and effective components of Belamcanda chinensis [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(02):366-373.
2. Valkω, Kl · ra. "Application of high-performance liquid chromatography based measurements of obesity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https:// doi.org/10.1016/j.chroma.2003.10.084
3. Valkω, Kl · ra. "Application of high-performance liquid chromatography based measurements of lipid model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084
4. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884

548-76-5 - Reference Information

biological activity	Irigenin is A lead compound that specifically and selectively blocks Extra Domain A (EDA) the α9β1 and α4β1 integrin binding sites on the C- C loop of the domain mediate its anti-metastatic effect. Irigenin has anti-cancer effects. It sensitizes TRAIL-induced apoptosis by enhancing the expression of pro-apoptotic molecules in gastric cancer cells.
Use	for content determination/identification/pharmacological experiments.

Last Update：2024-04-09 21:01:54