548470-11-7

548470-11-7 - Names and Identifiers

Name	N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE)
Synonyms	ISRIB Integrated Stress Response inhibitor N,N'-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] trans-N,N′-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) 2-(4-chlorophenoxy)-N-(4-{[(4-chlorophenoxy)acetyl]amino}cyclohexyl)acetami de 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide ISRIB N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE)
CAS	548470-11-7

548470-11-7 - Physico-chemical Properties

Molecular Formula	C22H24Cl2N2O4
Molar Mass	451.34
Density	1.33±0.1 g/cm3(Predicted)
Melting Point	270-273°C
Boling Point	719.0±60.0 °C(Predicted)
Solubility	DMSO: 1 mg/mL, clear (warmed)
Appearance	powder
Color	white to beige
pKa	13.63±0.40(Predicted)
Storage Condition	2-8°C

548470-11-7 - Risk and Safety

Hazard Symbols	N - Dangerous for the environment
Risk Codes	50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3

548470-11-7 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.216 ml	11.078 ml	22.156 ml
5 mM	0.443 ml	2.216 ml	4.431 ml
10 mM	0.222 ml	1.108 ml	2.216 ml
5 mM	0.044 ml	0.222 ml	0.443 ml

Last Update：2024-01-02 23:10:35

548470-11-7 - Introduction

N,N'-((1R,4R)-CYCLOHEXANE-1,4-diyl) BIS(2-(4-chroophenoxy) ACETAMIDE), also known as N,N'-dicyclohexyl-1,4-dioxane-2,5-dicarboxamide, the molecular formula C22H36ClNO4 is an organic compound.

Nature:
N,N'-((1R,4R)-CYCLOHEXANE-1,4-diyl) BIS(2-(4-chroophenoxy) ACETAMIDE) is a colorless crystalline solid with low solubility. It is a non-volatile solid at room temperature and has good thermal stability.

Use:
N,N'-((1R,4R)-CYCLOHEXANE-1,4-diyl) BIS(2-(4-chloroform) ACETAMIDE) is mainly used as a reaction aid and solvent in polymer materials. It can significantly increase the molecular weight of polyurethane and polyamide, improve the mechanical properties and thermal stability of the material. In addition, it can also be used in the fields of dyes, plastics, coatings and adhesives.

Preparation Method:
N,N'-((1R,4R)-CYCLOHEXANE-1,4-diyl) BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) can be prepared by 1, 4-Cyclohexanedione and 2-(4-chlorophenoxy) acetamide are reacted under acidic conditions. Heating is required during the reaction, and an appropriate amount of solvent is added to promote the reaction.

Safety Information:
N,N'-((1R,4R)-CYCLOHEXANE-1,4-diyl) BIS(2-(4-chroophenoxy) ACETAMIDE) has low toxicity under general operation, however, it is still necessary to follow reasonable laboratory practices. Care should be taken to avoid direct contact with skin, eyes or mucous membranes and to maintain good ventilation. If accidental contact, should immediately rinse with water, if necessary, seek medical attention.

Last Update：2024-04-10 22:29:15