554-12-1
Methyl propionate
CAS: 554-12-1
Molecular Formula: C4H8O2
554-12-1 - Names and Identifiers
| Name | Methyl propionate |
| Synonyms | methyl propanoate Methyl propionate METHYL PROPANOATE Propanoic acid methyl Propionic acid methyl Propanoic acid methyl ester Propionic acid methyl ester Methyl trianoate (Methyl propionate) Methyl Propionate [Standard Material for GC] |
| CAS | 554-12-1 |
| EINECS | 209-060-4 |
| InChI | InChI=1/C4H8O2/c1-3-4(5)6-2/h3H2,1-2H3 |
554-12-1 - Physico-chemical Properties
| Molecular Formula | C4H8O2 |
| Molar Mass | 88.11 |
| Density | 0.915 g/mL at 25 °C (lit.) |
| Melting Point | -88 °C (lit.) |
| Boling Point | 79 °C (lit.) |
| Flash Point | 43°F |
| JECFA Number | 141 |
| Water Solubility | 5 g/100 mL at 20 ºC |
| Solubility | H2O: soluble16 parts |
| Vapor Presure | 40 mm Hg ( 11 °C) |
| Vapor Density | 3 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless |
| Merck | 14,6112 |
| BRN | 1737628 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, bases. Readily forms explosive mixtures with air. Moisture sensitive. |
| Explosive Limit | 2.5-13%(V) |
| Refractive Index | n20/D 1.376(lit.) |
| Physical and Chemical Properties | Characteristics of colorless liquid, fruit flavor. melting point -87.5 ℃ boiling point 79.8 ℃ relative density 0.9150 refractive index 1.3775 flash point -2 ℃ solubility, hydrocarbons and other organic solvents miscible, slightly soluble in water. |
| Use | Used as pharmaceutical, pesticide, Fragrance Intermediates |
554-12-1 - Risk and Safety
| Risk Codes | R11 - Highly Flammable R20 - Harmful by inhalation R2017/11/20 - |
| Safety Description | S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S29 - Do not empty into drains. S33 - Take precautionary measures against static discharges. |
| UN IDs | UN 1248 3/PG 2 |
| WGK Germany | 1 |
| RTECS | UF5970000 |
| TSCA | Yes |
| HS Code | 2915 50 00 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 5000 mg/kg |
554-12-1 - Nature
Open Data Verified Data
colorless liquid with fruit aroma. The relative density was 0.9150. Melting Point -87.5 °c. Boiling point 79.8 °c. Flash point -2 °c. Refractive index 3775. With alcohol, ether, hydrocarbon and other organic solvents miscible, slightly soluble in water. Flammable.
Last Update：2024-01-02 23:10:35
554-12-1 - Preparation Method
Open Data Verified Data
propionic acid and methanol are esterified under sulfuric acid catalysis, and then neutralized and fractionated to obtain a finished product.
Last Update：2022-01-01 10:32:45
554-12-1 - Use
Open Data Verified Data
nitrocellulose solvent, used in Nitro paint, paint production, can also be used as a solvent for spices and spices. It is also used as an intermediate in organic synthesis.
Last Update：2022-01-01 10:32:45
554-12-1 - Safety
Open Data Verified Data
- This product has stimulatory and anesthetic effects. The lowest lethal dose in rats was 2550mg/kg. Mouse oral LD50 3460mg/kg, inhalation LD50 27000mg/m3
- iron drum packaging. According to flammable chemicals regulations
Last Update：2022-01-01 10:32:45
554-12-1 - Reference Information
| FEMA | 2742 | METHYL PROPIONATE |
| LogP | 0.8 at 26.6℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | GRAS(FEMA). LD50>5g/kg (rat, oral). |
| usage limit | FEMA(mg/kg): Soft drink 20; Cold drink 29; Candy 29; Baked product 130. FDA(§ 172.515,2000): moderate limits. |
| Use | used as an intermediate in medicine, pesticide and perfume used as a solvent for nitrocellulose, used in nitro spray paint, coating production, can also be used as a solvent for spices and spices. It is also used as an intermediate in organic synthesis. used as standard substance and solvent for chromatographic analysis used as solvent and producing perfume gas chromatographic analysis standard. Organic Synthesis. Solvent for nitrocellulose. |
| production method | is obtained by esterification of propionic acid with methanol. 5kg of propionic acid, 3kg of methanol and 300g of sulfuric acid were mixed and heated to reflux for 6-8H. The sulfuric acid layer was separated and the ester layer was cooled. The ester layer was washed with brine with the same volume of crude ester, washed with sodium carbonate solution until no acidity, and fractionated after drying to obtain 3.5L of methyl propionate. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 5000 mg/kg; Oral-mouse LD50: 3460 mg/kg |
| stimulation data | Skin-rabbit 500 mg/24 h moderate |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| Occupational Standard | SEL 10 mg/m3 |
| spontaneous combustion temperature | 876 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:09
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