Name | Nicardipine |
Synonyms | Nicardipine NicardipineBase benzylmethylamino)ethylmethylester 2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate Methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[methyl(benzyl)amino]ethyl]5-methyl ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methy(phenyl-methyl)amino]ethyl ester hydrochloride |
CAS | 55985-32-5 |
EINECS | 259-932-3 |
InChI | InChI=1/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3 |
Molecular Formula | C26H29N3O6 |
Molar Mass | 479.52 |
Density | 1.230±0.06 g/cm3(Predicted) |
Melting Point | 136-138 °C |
Boling Point | 603.4±55.0 °C(Predicted) |
Solubility | Dichloromethane; Methanol |
Appearance | Solid |
Color | Yellow |
pKa | 7.30±0.50(Predicted) |
Storage Condition | 2-8°C |
Physical and Chemical Properties | Yellow-green crystalline powder, from methanol/acetone in the precipitation of crystals can be separated from the alpha and beta two kinds of crystals, Alpha melting point 168-170 ℃; Beta melting point 179-181 ℃; the melting point of the mixed body was 168.4-169.4 °c. Soluble in methanol, acetic acid, chloroform, difficult to dissolve in anhydrous methanol, almost insoluble in water, propanol, ether and benzene. Odorless, slightly bitter, hygroscopic. |
Use | Vasodilator for the treatment of ischemic cerebrovascular disease and essential hypertension |