5608-24-2
PRIMA-1
CAS: 5608-24-2
Molecular Formula: C9H15NO3
5608-24-2 - Names and Identifiers
5608-24-2 - Physico-chemical Properties
| Molecular Formula | C9H15NO3 |
| Molar Mass | 185.22 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 146-147 °C |
| Boling Point | 353.7±17.0 °C(Predicted) |
| Water Solubility | Soluble in water at 10mg/ml |
| Solubility | H2O: >10mg/mL |
| Appearance | solid |
| Color | white to off-white |
| pKa | 13.68±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Light Sensitive |
| In vitro study | PRIMA-1 is converted to a thiol adduct-forming compound in p53 mutants. PRIMA-1 modifies the thiol group of the p53 mutant to restore its tumor suppressor activity. PRIMA-1 inhibits the growth of pancreatic cancer cells, induces cell cycle arrest and reduces DNA synthesis. It can selectively induce apoptosis and cell death in pancreatic cancer cells expressing p53 mutants, and activate p53-dependent apoptotic pathways. PRIMA-1 enhances the cytotoxicity of chemotherapeutic drugs on p53 mutant pancreatic cancer cells. PRIMA-1 has high antileukemic activity in NB4 cells derived from acute promyelocytic leukemia. The apoptosis induced by PRIMA-1 was time-dependent and dose-dependent. The apoptosis caused by it is related to the activation of caspase-9, caspase-7 and PARP fragmentation. PRIMA-1 had no significant apoptotic effect on normal human peripheral blood mononuclear cells. |
| In vivo study | The mice were injected intravenously, and the injection of PRIMA-1 did not result in any significant weight and behavioral differences (compared to the control group). In a mouse tumor model, PRIMA-1 has antitumor activity and is capable of p53 mutant-dependent tumor growth. |
5608-24-2 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
5608-24-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.399 ml | 26.995 ml | 53.99 ml |
| 5 mM | 1.08 ml | 5.399 ml | 10.798 ml |
| 10 mM | 0.54 ml | 2.699 ml | 5.399 ml |
| 5 mM | 0.108 ml | 0.54 ml | 1.08 ml |
Last Update：2024-01-02 23:10:35
5608-24-2 - Reference Information
| biological activity | PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinucidinone) is a reactivator of the p53 mutant. In human tumors carrying p53 mutations, apoptosis is caused and tumor growth is inhibited. |
| Target | Value |
Last Update：2024-04-09 20:52:54
Supplier List
Product Name: PRIMA-1 Visit Supplier Webpage Request for quotation
CAS: 5608-24-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 5608-24-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: PRIMA-1 Visit Supplier Webpage Request for quotation
CAS: 5608-24-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 5608-24-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History