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56211-40-6

Torasemide

CAS: 56211-40-6

Molecular Formula: C16H20N4O3S

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56211-40-6 - Names and Identifiers

Name Torasemide
Synonyms Demadex
DEMADEX
JDL-464
TroseMide
Torsemide
Torasemide
TorseMide API
Torasemide Tables
TorseMide(DeMadex)
1-[(4-anilino-3-pyridyl)sulfonyl]-3-isobutyl-urea
1-[4-(3-methylphenyl)aminopyridin-3-yl]sulfonyl-3-propan-2-yl-urea
N-(Isopropylcarbamoyl)-4-(m-tolylamino)pyridine-3-sulfonamideTorasemide
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
CAS 56211-40-6
EINECS 637-197-3
InChI InChI=1/C16H20N4O3S/c1-12(2)10-18-16(21)20-24(22,23)15-11-17-9-8-14(15)19-13-6-4-3-5-7-13/h3-9,11-12H,10H2,1-2H3,(H,17,19)(H2,18,20,21)
InChIKey NGBFQHCMQULJNZ-UHFFFAOYSA-N

56211-40-6 - Physico-chemical Properties

Molecular FormulaC16H20N4O3S
Molar Mass348.42
Density1.283±0.06 g/cm3(Predicted)
Melting Point163-164°C
Boling Point163-164℃
Water SolubilitySoluble
Solubility DMSO: soluble18mg/mL
Appearancesolid
ColorWhite
Merck14,9552
pKa6.44(at 25℃)
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
Refractive Index1.594
Physical and Chemical PropertiesMelting Point: 163-164°C
solubility: Soluble
UseUsed as a diuretic
In vitro studyTorsemide inhibits the secretion of aldosterone by murine, bovine, and guinea-pig adrenal cells, stimulated by angiotensin, butyrylcyclic AMP, ACTH, or corticosterone in vitro. The main site of action of Torsemide is the upper Henle circulation of the kidney, which promotes the excretion of sodium, water and chloride by interacting with the Na ,K ,2Cl-transport. Torsemide interferes with mineralocortical aldosterone secretion and binding in a dose-dependent manner.
In vivo studyIn dogs with mitral valve closure, Torsemide causes elevated levels of circulating angiotensin II and aldosterone (which support interference with aldosterone at the receptor level), whereas furosemide only increases levels of angiotensin II. In rats, Torsemide increased blood urea nitrogen and plasma creatinine concentrations compared to baseline values. Torsemide immediately increased urine output significantly.

56211-40-6 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR36 - Irritating to the eyes
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany2
RTECSUT7938000
HS Code2935904000
56211-40-6
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Torasemide Request for quotation
CAS: 56211-40-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: N-[[(1-Methylethyl)Amino]Carbonyl]-4-[(3-Methylphenyl)Amino]-3-Pyridinesulfonamide Visit Supplier Webpage Request for quotation
CAS: 56211-40-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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56211-40-6
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