56472-29-8

Name	2-Hydroxy Oleic Acid
Synonyms	Minerval 2-HYDROXYOLEICACID α-Hydroxyoleic Acid 2-Hydroxy Oleic Acid cis-2-Hydroxy-9-octadecenoic Acid (Z)-2-Hydroxyoctadec-9-enoic acid (9Z)-2-Hydroxy-9-octadecenoic Acid (9Z)-2-Hydroxy-9-octadecenoic Acid-d17 2-Hydroxy Oleic Acid (Mixture of Z and E IsoMers)
CAS	56472-29-8

Hazard Symbols	Xi - Irritant
Risk Codes	41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
WGK Germany	3

biological activity	Minerval (2-hydroethylic acid) is a synthetic oleic acid (OA) derivative, capable of binding to the plasma membrane to alter lipid tissue. Minerval has anti-tumor effects.
Cell Line:	Jurkat cells Jurkat cells
Concentration:	25 μM, 50 μM, 75 μM 25 μM, 50 μM
Incubation Time:	24 hours, 48 hours, 72 hours 72 hours
Result:	Impaired Jurkat cell growth in a time- and concentration-dependent manner. Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP. Markedly and significantly inhibited tumour growth.
Animal Model:	6-week-old nude male mice (Jurkat cells xenograft model)
Dosage:	600 mg/kg
Administration:	Oral administration; daily; for 21 days

Last Update：2024-04-10 22:29:15

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